TPX2 antibody (C-Term)
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- Target See all TPX2 Antibodies
- TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TPX2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- DIL-2 Antibody detects endogenous levels of total DIL-2.
- Predicted Reactivity
- Pig,Bovine,Horse,Sheep,Rabbit,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human DIL-2, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
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anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) antibody
TPX2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IP, ICC Host: Mouse Monoclonal TPX2-01 unconjugated
anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) (AA 160-320) antibodyTPX2 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) (AA 350-382) antibodyTPX2 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB0559 unconjugated
anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) antibodyTPX2 Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) (AA 1-220) antibodyTPX2 Reactivity: Human WB, IHC (p) Host: Mouse Monoclonal 18D5 unconjugated
anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) (C-Term) antibodyTPX2 Reactivity: Human, Mouse, Rat, Guinea Pig, Cow, Dog, Horse, Rabbit WB Host: Rabbit Polyclonal unconjugated
anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) (Internal Region) antibodyTPX2 Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) (AA 551-650) antibodyTPX2 Reactivity: Mouse WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) (AA 1-531) antibodyTPX2 Reactivity: Human WB Host: Mouse Monoclonal 1696CT464-66-9 unconjugated
anti-TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2) (multi Epitope) antibodyTPX2 Reactivity: Human, Mouse WB Host: Mouse Monoclonal 19AT953-286-93 unconjugated
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- Application Notes
- WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- TPX2 (TPX2, Microtubule-Associated, Homolog (Xenopus Laevis) (TPX2))
- Alternative Name
- TPX2 (TPX2 Products)
- Synonyms
- C20orf1 antibody, C20orf2 antibody, DIL-2 antibody, DIL2 antibody, FLS353 antibody, GD:C20orf1 antibody, HCA519 antibody, HCTP4 antibody, REPP86 antibody, p100 antibody, 2610005B21Rik antibody, TPX2 antibody, dil-2 antibody, dil2 antibody, hctp4 antibody, repp86 antibody, tpx2 antibody, TPX2, microtubule nucleation factor antibody, TPX2, microtubule-associated antibody, TPX2, microtubule-associated, homolog (Xenopus laevis) antibody, TPX2, microtubule-associated S homeolog antibody, TPX2, microtubule-associated L homeolog antibody, TPX2 antibody, Tpx2 antibody, tpx2.S antibody, tpx2.L antibody
- Background
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Description: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
Gene: TPX2
- Molecular Weight
- 85 kDa
- Gene ID
- 22974
- UniProt
- Q9ULW0
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