PSME4 antibody (AA 105-198)
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- Target See all PSME4 Antibodies
- PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
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Binding Specificity
- AA 105-198
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PSME4 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Proteasome activator complex subunit 4 protein (105-198AA)
- Isotype
- IgG
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anti-Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4) (AA 503-535) antibody
PSME4 Reactivity: Human WB Host: Rabbit Polyclonal RB55279 unconjugated
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- Application Notes
- Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))
- Alternative Name
- PSME4 (PSME4 Products)
- Synonyms
- proteasome activating protein 200 antibody, Afu4g11290 antibody, An04g05320 antibody, AO090003001091 antibody, PA200 antibody, AA409398 antibody, AU041366 antibody, TEMO antibody, mKIAA0077 antibody, proteasome activator subunit 4 antibody, proteasome activating protein 200 antibody, proteasome (prosome, macropain) activator subunit 4 antibody, PSME4 antibody, Psme4 antibody, PA200 antibody, AFUA_4G11290 antibody, ANI_1_888184 antibody, AOR_1_1944154 antibody, TERG_07227 antibody, psme4 antibody
- Background
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Background: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Aliases: KIAA0077 antibody, PA200 antibody, Proteasome Activator 200 kDa antibody, Proteasome activator complex subunit 4 antibody, Proteasome activator PA200 antibody, PSME 4 antibody, psme4 antibody, PSME4_HUMAN antibody
- UniProt
- Q14997
- Pathways
- DNA Replication, Synthesis of DNA
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