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GATA2 antibody (N-Term)

GATA2 Reactivity: Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse WB, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2777458
  • Target See all GATA2 Antibodies
    GATA2 (GATA Binding Protein 2 (GATA2))
    Binding Specificity
    • 25
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 78
    • 34
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat, Rabbit, Cow, Dog, Guinea Pig, Horse
    Host
    • 76
    • 3
    Rabbit
    Clonality
    • 74
    • 5
    Polyclonal
    Conjugate
    • 37
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This GATA2 antibody is un-conjugated
    Application
    • 61
    • 20
    • 13
    • 13
    • 10
    • 7
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Sequence
    PYYANPAHAR ARVSYSPAHA RLTGGQMCRP HLLHSPGLPW LDGGKAALSA
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
    Characteristics
    This is a rabbit polyclonal antibody against GATA2. It was validated on Western Blot and immunohistochemistry.
    Purification
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human GATA2
    Top Product
    Discover our top product GATA2 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 480 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Wang, Zhu, Guo, Dong, Liu, Yin, Zhang, Li, Liu, Ma, Song, He, Wang, Wang, Zhang, Li, Yu: "A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis." in: Nucleic acids research, Vol. 42, Issue 1, pp. 442-57, (2013) (PubMed).

    Fujiwara, Yokoyama, Okitsu, Kamata, Fukuhara, Onishi, Fujimaki, Takahashi, Ishizawa, Bresnick, Harigae: "Gene expression profiling identifies HOXB4 as a direct downstream target of GATA-2 in human CD34+ hematopoietic cells." in: PLoS ONE, Vol. 7, Issue 9, pp. e40959, (2012) (PubMed).

    Jack, Crossley: "GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis." in: The Journal of biological chemistry, Vol. 285, Issue 42, pp. 32405-14, (2010) (PubMed).

    Huang, Niu, Liu, Wang, Sturgis, Wei: "The functional IGFBP7 promoter -418G>A polymorphism and risk of head and neck cancer." in: Mutation research, Vol. 702, Issue 1, pp. 32-9, (2010) (PubMed).

    Mammoto, Connor, Mammoto, Yung, Huh, Aderman, Mostoslavsky, Smith, Ingber: "A mechanosensitive transcriptional mechanism that controls angiogenesis." in: Nature, Vol. 457, Issue 7233, pp. 1103-8, (2009) (PubMed).

    Tsuzuki, Kitajima, Nakano, Glasow, Zelent, Enver: "Cross talk between retinoic acid signaling and transcription factor GATA-2." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6824-36, (2004) (PubMed).

  • Target
    GATA2 (GATA Binding Protein 2 (GATA2))
    Alternative Name
    GATA2 (GATA2 Products)
    Synonyms
    DCML antibody, MONOMAC antibody, NFE1B antibody, Gata-2 antibody, xgata-2 antibody, xgata2 antibody, GATA-2 antibody, NF-E1b antibody, GATA2 antibody, Gata2 antibody, gata2 antibody, zg2 antibody, zgc:91840 antibody, GATA binding protein 2 antibody, GATA binding protein 2 L homeolog antibody, amidase antibody, glutamyl/aspartyl-tRNA(Gln/Asp) amidotransferasesubunit A antibody, hypothetical protein antibody, glutamyl-tRNA(Gln) amidotransferase, subunit GatA (Glu-ADT subunit A) antibody, GATA2 transcription factor antibody, putative gata binding factor antibody, GATA binding protein 2a antibody, GATA binding protein 2b antibody, GATA2 antibody, Gata2 antibody, gata2.L antibody, RR_RS20245 antibody, gatA2 antibody, Smp_018590 antibody, gata2a antibody, gata2b antibody
    Background
    The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells is essential for normal primitive and definitive erythropoiesis and is expressed at high levels in erythroid cells, mast cells, and megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells.
    Alias Symbols: DCML, NFE1B, MONOMAC
    Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-9, KRT40, PRR20A, ADAMTSL4, TRAF1, PSMA3, MDFI, GOLGA2, FHL3, TRIM23, AKT1, BMI1, SPI1, SMAD4, ELAVL1, KAT2A, EP300, MED1, POU1F1, POU2AF1, ZBTB32, ZFPM1, ZBTB16, HDAC5, HDAC3, HHEX, RARA, RXRA, MAPK1, JUN, CEBPA, STAT3, PML,
    Protein Size: 480
    Molecular Weight
    50 kDa
    Gene ID
    2624
    NCBI Accession
    NM_032638, NP_116027
    UniProt
    P23769
    Pathways
    Stem Cell Maintenance
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