NPHP4 antibody (AA 397-543)
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- Target See all NPHP4 Antibodies
- NPHP4 (Nephronophthisis 4 (NPHP4))
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Binding Specificity
- AA 397-543
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NPHP4 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Nephrocystin-4 protein (397-543AA)
- Isotype
- IgG
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anti-Nephronophthisis 4 (NPHP4) (AA 1247-1426) antibody
NPHP4 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Nephronophthisis 4 (NPHP4) (AA 877-926) antibodyNPHP4 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: IHC:1:500-1:1000, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- NPHP4 (Nephronophthisis 4 (NPHP4))
- Alternative Name
- NPHP4 (NPHP4 Products)
- Synonyms
- NPHP4 antibody, POC10 antibody, SLSN4 antibody, 4930564O18Rik antibody, nmf192 antibody, nephrocystin 4 antibody, nephrocystin-4 antibody, nephronophthisis 4 (juvenile) homolog (human) antibody, NPHP4 antibody, LOC100184720 antibody, Nphp4 antibody
- Background
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Background: Involved in the organization of apical junctions, the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).
Aliases: KIAA0673 antibody, Nephrocystin-4 antibody, nephronophthisis 4 antibody, Nephroretinin antibody, NPHP4 antibody, NPHP4_HUMAN antibody, POC10 antibody, POC10 centriolar protein homolog antibody, SLSN4 antibody
- UniProt
- O75161
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