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FBXO9 antibody (AA 13-111)

FBXO9 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7152451
  • Target See all FBXO9 Antibodies
    FBXO9 (F-Box Protein 9 (FBXO9))
    Binding Specificity
    • 15
    • 9
    • 8
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 13-111
    Reactivity
    • 42
    • 20
    • 15
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 53
    • 4
    Rabbit
    Clonality
    • 55
    • 2
    Polyclonal
    Conjugate
    • 20
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This FBXO9 antibody is un-conjugated
    Application
    • 41
    • 29
    • 14
    • 13
    • 13
    • 6
    • 6
    • 4
    • 3
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human F-box only protein 9 protein (13-111AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    FBXO9 (F-Box Protein 9 (FBXO9))
    Alternative Name
    FBXO9 (FBXO9 Products)
    Synonyms
    fbxo9 antibody, MGC75727 antibody, FBXO9 antibody, fbx9 antibody, FBX9 antibody, NY-REN-57 antibody, VCIA1 antibody, dJ341E18.2 antibody, wu:fc79g12 antibody, zgc:56212 antibody, zgc:77654 antibody, 9030401P18Rik antibody, AA986398 antibody, F-box protein 9 antibody, F-box only protein 9 antibody, f-box protein 9 antibody, F-box protein 9 L homeolog antibody, fbxo9 antibody, FBXO9 antibody, CpipJ_CPIJ012920 antibody, Tsp_03945 antibody, fbx9 antibody, Fbxo9 antibody, fbxo9.L antibody
    Background

    Background: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

    Aliases: Cross-immune reaction antigen 1 antibody, dJ341E18.2 antibody, DKFZp434C0118 antibody, F-box only protein 9 antibody, Fbp24 antibody, FBX09 antibody, FBX9 antibody, FBX9_HUMAN antibody, Fbxo9 antibody, KIAA0936 antibody, NY REN 57 antibody, OTTHUMP00000016628 antibody, OTTHUMP00000016629 antibody, OTTHUMP00000214588 antibody, Renal carcinoma antigen NY-REN-57 antibody, VCIA1 antibody

    UniProt
    Q9UK97
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