LATS2 antibody (pSer83)
(1 reference)-
- Target See all LATS2 Antibodies
- LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
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Binding Specificity
- pSer83
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This LATS2 antibody is un-conjugated
- Application
- ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Specificity
- This phosphorylation site is homologous to that of Ser82 in Mouse and Ser83 Rat.
- Cross-Reactivity
- Human, Mouse, Rat
- Predicted Reactivity
- Dog,Cow,Pig,Horse
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human LATS2 around the phosphorylation site of Ser83
- Isotype
- IgG
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anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1000-1027), (C-Term) antibody
LATS2 Reactivity: Mouse WB, IHC (p) Host: Rabbit Polyclonal RB40566 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 195-224) antibodyLATS2 Reactivity: Human, Mouse ELISA, WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1-100) antibodyLATS2 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 Reactivity: Human IHC (p) Host: Rabbit Polyclonal RB3032 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) antibodyLATS2 Reactivity: Human, Mouse ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (pSer83) antibodyLATS2 Reactivity: Human ELISA, WB Host: Mouse Monoclonal ST-3B11 unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 228-258) antibodyLATS2 Reactivity: Human, Mouse ELISA, WB, IHC Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1022-1140) antibodyLATS2 Reactivity: Zebrafish (Danio rerio) ELISA, WB Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 541-590) antibodyLATS2 Reactivity: Human, Mouse ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2) (AA 1000-1027) antibodyLATS2 Reactivity: Mouse ELISA, WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
-
-
: "Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence." in: Oncotarget, Vol. 9, Issue 2, pp. 2175-2192, (2018) (PubMed).
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: "Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence." in: Oncotarget, Vol. 9, Issue 2, pp. 2175-2192, (2018) (PubMed).
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- Target
- LATS2 (LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
- Alternative Name
- LATS2 (LATS2 Products)
- Synonyms
- 4932411G09Rik antibody, AV277261 antibody, AW228608 antibody, KPM antibody, lats2 antibody, large tumor suppressor kinase 2 antibody, large tumor suppressor 2 antibody, LATS2 antibody, Lats2 antibody, lats2 antibody
- Background
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Synonyms: KPM, Serine/threonine-protein kinase LATS2, Kinase phosphorylated during mitosis protein, Large tumor suppressor homolog 2, Serine/threonine-protein kinase kpm, Warts-like kinase, LATS2
Background: Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
- Gene ID
- 26524
- UniProt
- Q9NRM7
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