EIF2AK1 antibody
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- Target See all EIF2AK1 Antibodies
- EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This EIF2AK1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human, Rat
- Purification
- Affinity purification
- Immunogen
- Recombinant protein corresponding to Mouse Heme-regulated inhibitor
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anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 1-86) antibody
EIF2AK1 Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (N-Term) antibodyEIF2AK1 Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio) WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 108-157) antibodyEIF2AK1 Reactivity: Human, Mouse, Rat, Monkey, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish (Danio rerio), Bat, Pig WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 34-180) antibodyEIF2AK1 Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (C-Term) antibodyEIF2AK1 Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 1-30), (N-Term) antibodyEIF2AK1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB3304 unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 267-296) antibodyEIF2AK1 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB12521 unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) antibodyEIF2AK1 Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 1-630) antibodyEIF2AK1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1) (AA 371-630) antibodyEIF2AK1 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB (H,M,R) 1 :500-1: 1000, IHC/IF (M,R) 1:800-1:1600/1:500-1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS, pH 7.4, 0.02 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
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- Target
- EIF2AK1 (Eukaryotic Translation Initiation Factor 2-alpha Kinase 1 (EIF2AK1))
- Alternative Name
- Heme-regulated inhibitor (EIF2AK1 Products)
- Synonyms
- HCR antibody, Hri antibody, HRI antibody, wu:fj97h09 antibody, zgc:153232 antibody, eukaryotic translation initiation factor 2 alpha kinase 1 antibody, eukaryotic translation initiation factor 2-alpha kinase 1 antibody, eukaryotic translation initiation factor 2 alpha kinase 1 L homeolog antibody, EIF2AK1 antibody, eif2ak1 antibody, Eif2ak1 antibody, eif2ak1.L antibody
- Background
- The Eif2ak1 Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells, controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties.
- Molecular Weight
- 70 kDa
- Gene ID
- 15467
- NCBI Accession
- NP_038585
- UniProt
- Q9Z2R9
- Pathways
- Hepatitis C
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