SNX5 antibody (AA 7-245)
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- Target See all SNX5 Antibodies
- SNX5 (Sorting Nexin 5 (SNX5))
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Binding Specificity
- AA 7-245
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SNX5 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Sorting nexin-5 protein (7-245AA)
- Isotype
- IgG
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anti-Sorting Nexin 5 (SNX5) antibody
SNX5 Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (C-Term) antibodyVerified SNX5 Reactivity: Human WB, ELISA, IHC Host: Goat Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (AA 43-70), (N-Term) antibodySNX5 Reactivity: Human WB Host: Rabbit Polyclonal RB42916 unconjugated
anti-Sorting Nexin 5 (SNX5) (C-Term) antibody (Biotin)Verified SNX5 Reactivity: Human WB, ELISA, IHC Host: Goat Polyclonal Biotin
anti-Sorting Nexin 5 (SNX5) antibodySNX5 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (AA 31-80) antibodySNX5 Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Horse, Rabbit, Zebrafish (Danio rerio), Monkey, Guinea Pig, Chicken WB Host: Rabbit Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (AA 72-121) antibodySNX5 Reactivity: Human, Mouse, Rat, Cow, Dog, Pig, Horse, Rabbit, Zebrafish (Danio rerio), Monkey, Bat WB Host: Rabbit Polyclonal unconjugated
anti-Sorting Nexin 5 (SNX5) (AA 145-404) antibodySNX5 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: WB:1:1000-1:5000, IHC:1:500-1:1000, IF:1:200-1:500,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- SNX5 (Sorting Nexin 5 (SNX5))
- Alternative Name
- SNX5 (SNX5 Products)
- Synonyms
- 0910001N05Rik antibody, 1810032P22Rik antibody, AU019504 antibody, D2Ertd52e antibody, id:ibd5091 antibody, wu:fa66c10 antibody, wu:fi28h04 antibody, zgc:55769 antibody, SNX5 antibody, snx5 antibody, sorting nexin 5 antibody, sorting nexin 5 S homeolog antibody, SNX5 antibody, Snx5 antibody, snx5.S antibody, snx5 antibody
- Background
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Background: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:15561769). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235). May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation, the function involves PIP5K1C isoform 3 and is retromer-independent (PubMed:23602387). Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation, inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941).
Aliases: 0910001N05Rik antibody, 1810032P22Rik antibody, AU019504 antibody, D2Ertd52e antibody, FLJ10931 antibody, OTTHUMP00000030340 antibody, OTTHUMP00000062927 antibody, OTTMUSP00000003367 antibody, OTTMUSP00000003368 antibody, RP11-504H3.2 antibody, RP23-35E16.2 antibody, snoRNA MBI-43 antibody, SNX 5 antibody, SNX5 antibody, SNX5_HUMAN antibody, Sorting nexin 5 antibody, Sorting nexin-5 antibody
- UniProt
- Q9Y5X3
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