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GLRA1 antibody (AA 23-113)

GLRA1 Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7154186
  • Target See all GLRA1 Antibodies
    GLRA1 (Glycine Receptor, alpha 1 (GLRA1))
    Binding Specificity
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 23-113
    Reactivity
    • 30
    • 16
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 26
    • 4
    • 1
    Rabbit
    Clonality
    • 26
    • 4
    Polyclonal
    Conjugate
    • 20
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GLRA1 antibody is un-conjugated
    Application
    • 19
    • 11
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Glycine receptor subunit alpha-1 protein (23-113AA)
    Isotype
    IgG
  • Application Notes
    Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    GLRA1 (Glycine Receptor, alpha 1 (GLRA1))
    Alternative Name
    GLRA1 (GLRA1 Products)
    Synonyms
    GLYRA1 antibody, HKPX1 antibody, STHE antibody, [a]Z1 antibody, B230397M16Rik antibody, nmf11 antibody, oscillator antibody, ot antibody, spasmodic antibody, spd antibody, glycine receptor alpha 1 antibody, glycine receptor, alpha 1 antibody, glycine receptor, alpha 1 subunit antibody, GLRA1 antibody, Glra1 antibody, glra1 antibody
    Background

    Background: Glycine receptors are ligand-gated chloride channels (PubMed:23994010, PubMed:25730860). Channel opening is triggered by extracellular glycine (PubMed:2155780, PubMed:7920629, PubMed:14551753, PubMed:16144831, PubMed:22715885, PubMed:22973015, PubMed:25973519, PubMed:9009272). Channel opening is also triggered by taurine and beta-alanine (PubMed:16144831, PubMed:9009272). Channel characteristics depend on the subunit composition, heteropentameric channels are activated by lower glycine levels and display faster desensitization (PubMed:14551753). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels ot ethanol contribute to the sedative effects of ethanol (By similarity).

    Aliases: GLRA1 antibody, GLRA1_HUMAN antibody, Glycine receptor 48 kDa subunit antibody, Glycine receptor alpha 1 antibody, Glycine receptor strychnine-binding subunit antibody, Glycine receptor subunit alpha-1 antibody, Glycine receptor, alpha 1 subunit antibody, HKPX1 antibody, STHE antibody

    UniProt
    P23415
    Pathways
    Synaptic Membrane
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