Desmocollin 2 antibody (Extracellular Domain)
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- Target See all Desmocollin 2 (DSC2) Antibodies
- Desmocollin 2 (DSC2)
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Binding Specificity
- Extracellular Domain
- Reactivity
- Human, Mouse, Rat
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Desmocollin 2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Staining Methods (StM)
- Purification
- Purified by Protein A/G
- Immunogen
- Human desmocollin-2 extracellular domain
- Clone
- 7G6
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product DSC2 Primary Antibody
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anti-Desmocollin 2 (DSC2) (AA 444-534) antibody
DSC2 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 1F2 unconjugated
anti-Desmocollin 2 (DSC2) antibodyDSC2 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 1-847) antibodyDSC2 Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) antibodyDSC2 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 136-471) antibodyDSC2 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 520-690) antibodyDSC2 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 520-690) antibodyDSC2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) (AA 1-847) antibodyDSC2 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Desmocollin 2 (DSC2) antibodyDSC2 Reactivity: Human, Mouse, Rat ELISA, Coat Host: Mouse Monoclonal rDSC2-3437 unconjugated Recombinant Antibody
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- Application Notes
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Positive Control: HeLa cells. Skin tissue.
Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Expiry Date
- 24 months
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- Target
- Desmocollin 2 (DSC2)
- Alternative Name
- DSC2 (DSC2 Products)
- Synonyms
- ARVD11 antibody, CDHF2 antibody, DG2 antibody, DGII/III antibody, DSC3 antibody, AW228162 antibody, Dsc2a antibody, Dsc2b antibody, DSC2 antibody, desmocollin 2 antibody, DSC2 antibody, Dsc2 antibody
- Background
- Desmosomes are intercellular adhering junctions that represent cell surface attachment sites for intermediate filament. The desmosome is subdivided into two regions. The plaque region lies adjacent to the plasma, and is believed to contain molecules that attach the intermediate filament cytoskeleton to the desmosome. The core region is composed of transmembrane glycoproteins that are thought to mediate cell-cell adhesion. Desmogleins and desmocollins are the main desmosomal transmembrane proteins. These desmosomal glycoproteins belong to the members of the cadherin family of adhesion molecules. Three different isoforms of both desmogleins and desmocollins have been identified, named as desmoglein 1-3 and desmocollins. Desmosomal cadherins showed differentiation-specific expression in the human epidermis, although the functional significance of this differential expression is not fully understood. Desmocollin-1 can be found in the upper layers. The expression of desmocollin-2 varies in the basal and suprabasal layers. And desmocollin-3 is expressed more evenly throughout the suprabasal layers.
- Molecular Weight
- 110kDa (DSC2), 100kDa (DSC3)
- Gene ID
- 1824
- UniProt
- Q02487
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