RASGRP1 antibody (C-Term)
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- Target See all RASGRP1 Antibodies
- RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))
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Binding Specificity
- C-Term
- Reactivity
- Human, Guinea Pig, Mouse, Rabbit, Dog, Horse, Rat, Cow
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RASGRP1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LGAKDLLHAP EEGPFTFPNG EAVEHGEESK DRTIMLMGVS SQKISLRLKR
- Predicted Reactivity
- Cow: 86%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against RASGRP1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Top Product
- Discover our top product RASGRP1 Primary Antibody
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anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 495-521) antibody
RASGRP1 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB21940 unconjugated
anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 598-797) antibodyRASGRP1 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 594-716) antibodyRASGRP1 Reactivity: Human ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1) (AA 617-666) antibodyRASGRP1 Reactivity: Human, Guinea Pig, Mouse, Rabbit WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 797 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- RASGRP1 (RAS Guanyl Releasing Protein 1 (Calcium and DAG-Regulated) (RASGRP1))
- Alternative Name
- RASGRP1 (RASGRP1 Products)
- Synonyms
- Rasgrp antibody, CALDAG-GEFI antibody, CALDAG-GEFII antibody, RASGRP antibody, V antibody, hRasGRP1 antibody, RAS guanyl releasing protein 1 antibody, Rasgrp1 antibody, RASGRP1 antibody
- Background
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This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Alias Symbols: CALDAG-GEFI, CALDAG-GEFII, MGC129998, MGC129999, RASGRP, V, hRasGRP1
Protein Interaction Partner: Dlg4, ABCB8, DGKZ, HRAS, VHL, PPM1B,
Protein Size: 797 - Molecular Weight
- 90 kDa
- Gene ID
- 10125
- NCBI Accession
- NM_005739, NP_005730
- UniProt
- O95267
- Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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