EH-Domain Containing 3 (EHD3) (Middle Region) Peptide
EHD3
Reactivity: Human
Host: Synthetic
BP, WB
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- Target See all EHD3 products
- EHD3 (EH-Domain Containing 3 (EHD3))
- Protein Region
- Middle Region
- Origin
- Human
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Source
- Synthetic
- Application
- Blocking Peptide (BP), Western Blotting (WB)
- Sequence
- DNKKKELVNN LAEIYGRIER EHQISPGDFP NLKRMQDQLQ AQDFSKFQPL
- Characteristics
- This is a synthetic peptide designed for use in combination with anti- EHD3 Antibody. It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
- Storage
- -20 °C
- Storage Comment
- For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
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- Target
- EHD3 (EH-Domain Containing 3 (EHD3))
- Synonyms
- PAST3 Peptide, Ehd2 Peptide, EHD3 Peptide, si:ch211-147c1.2 Peptide, MGC146452 Peptide, EH domain containing 3 Peptide, EH-domain containing 3 Peptide, EH domain containing 3 L homeolog Peptide, EHD3 Peptide, Ehd3 Peptide, ehd3 Peptide, ehd3.L Peptide
- Background
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ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes tubulation of endocytic membranes. Binding to phosphatidic acid induces its membrane tubulation activity. Plays a role in endocytic transport. Involved in early endosome to recycling endosome compartment (ERC), retrograde early endosome to Golgi, and endosome to plasma membrane (rapid recycling) protein transport. Involved in the regulation of Golgi maintenance and morphology. Involved in the recycling of internalized D1 dopamine receptor. Plays a role in cardiac protein trafficking probably implicating ANK2. Involved in the ventricular membrane targeting of SLC8A1 and CACNA1C and probably the atrial membrane localization of CACNA1GG and CACNA1H implicated in the regulation of atrial myocyte excitability and cardiac conduction. In conjunction with EHD4 may be involved in endocytic trafficking of KDR/VEGFR2 implicated in control of glomerular function. Involved in the rapid recycling of integrin beta-3 implicated in cell adhesion maintenance (PubMed:23781025). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle, an early step in cilium biogenesis, possibly sharing redundant functions with EHD.
Alias Symbols: PAST3
Protein Size: 535 - Gene ID
- 30845
- NCBI Accession
- NM_014600, NP_055415
- UniProt
- Q9NZN3
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