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HLA-DQA2 antibody (AA 39-66)

HLA-DQA2 Reactivity: Human WB Host: Rabbit Polyclonal RB42054 unconjugated
Catalog No. ABIN1881421
  • Target See all HLA-DQA2 Antibodies
    HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))
    Binding Specificity
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 39-66
    Reactivity
    • 28
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 27
    • 2
    Rabbit
    Clonality
    • 29
    Polyclonal
    Conjugate
    • 11
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HLA-DQA2 antibody is un-conjugated
    Application
    • 19
    • 16
    • 5
    Western Blotting (WB)
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This HLA-DQA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human HLA-DQA2.
    Clone
    RB42054
    Isotype
    Ig Fraction
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Hor, Kutalik, Dauvilliers, Valsesia, Lammers, Donjacour, Iranzo, Santamaria, Peraita Adrados, Vicario, Overeem, Arnulf, Theodorou, Jennum, Knudsen, Bassetti: "Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy." in: Nature genetics, Vol. 42, Issue 9, pp. 786-9, (2010) (PubMed).

    Petukhova, Duvic, Hordinsky, Norris, Price, Shimomura, Kim, Singh, Lee, Chen, Meyer, Paus, Jahoda, Amos, Gregersen, Christiano: "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity." in: Nature, Vol. 466, Issue 7302, pp. 113-7, (2010) (PubMed).

    Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, (2010) (PubMed).

    Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

  • Target
    HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))
    Alternative Name
    HLA-DQA2 (HLA-DQA2 Products)
    Synonyms
    DX-ALPHA antibody, HLA-DXA antibody, major histocompatibility complex, class II, DQ alpha 2 antibody, HLA-DQA2 antibody
    Background
    This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq].
    Molecular Weight
    28033
    NCBI Accession
    NP_064440
    UniProt
    P01906
    Pathways
    TCR Signaling
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