HMGCR antibody (AA 629-888)
(2 references)-
- Target See all HMGCR Antibodies
- HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
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Binding Specificity
- AA 629-888
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This HMGCR antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Sequence
- ARLQKLHTSI AGRNLYIRFQ SRSGDAMGMN MISKGTEKAL SKLHEYFPEM QILAVSGNYC TDKKPAAINW IEGRGKSVVC EAVIPAKVVR EVLKTTTEAM IEVNINKNLV GSAMAGSIGG YNAHAANIVT AIYIACGQDA AQNVGSSNCI TLMEASGPTN EDLYISCTMP SIEIGTVGGG TNLLPQQACL QMLGVQGACK DNPGENARQL ARIVCGTVMA GELSLMAALA AGHLVKSHMI HNRSKINLQD LQGACTKKTA
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 629-888 of human HMGCR (NP_000850.1).
- Isotype
- IgG
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anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 638-887) antibody
HMGCR Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (pSer872) antibodyHMGCR Reactivity: Human, Rat, Mouse WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 588-887) antibodyHMGCR Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (N-Term) antibodyHMGCR Reactivity: Human, Rat, Mouse WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) antibodyHMGCR Reactivity: Human, Rat, Mouse IHC, IF Host: Rabbit Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (AA 251-350) antibodyHMGCR Reactivity: Human, Rat, Mouse WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) (Internal Region) antibodyVerified HMGCR Reactivity: Human ELISA, IF, FACS Host: Goat Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) antibodyHMGCR Reactivity: Human, Rat, Mouse IHC Host: Rabbit Polyclonal unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) antibodyHMGCR Reactivity: Human WB, IHC (p) Host: Mouse Monoclonal CL0259 unconjugated
anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) antibodyHMGCR Reactivity: Human WB, IHC (p) Host: Mouse Monoclonal CL0260 unconjugated
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- Application Notes
- WB,1:1000 - 1:4000,IHC,1:50 - 1:100,IF,1:50 - 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid freeze / thaw cycles
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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: "MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice." in: Cell death & disease, Vol. 8, Issue 7, pp. e2916, (2018) (PubMed).
: "Effects of sepsis on the metabolism of sphingomyelin and cholesterol in mice with liver dysfunction." in: Experimental and therapeutic medicine, Vol. 14, Issue 6, pp. 5635-5640, (2017) (PubMed).
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: "MicroRNA-148a deficiency promotes hepatic lipid metabolism and hepatocarcinogenesis in mice." in: Cell death & disease, Vol. 8, Issue 7, pp. e2916, (2018) (PubMed).
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- Target
- HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
- Alternative Name
- HMGCR (HMGCR Products)
- Synonyms
- HMGR antibody, LDLCQ3 antibody, hmg-coa-r antibody, HMG-CoAR antibody, Red antibody, 3H3M antibody, BcDNA:LD15354 antibody, CG10367 antibody, Clb antibody, DmHMG-CoAr antibody, Dmel\\CG10367 antibody, HMGCR antibody, HMGCR_Dm antibody, HMGCoAR antibody, HMGCoARr antibody, HMGCoAr antibody, HmG-CoAR antibody, Hmg antibody, bro1 antibody, bs32f05.y1 antibody, clb antibody, hmgc antibody, hmgcr antibody, hmgrc antibody, l(3)01152 antibody, l(3)04684 antibody, hmgcr2 antibody, im:6912716 antibody, zgc:110746 antibody, 3-hydroxy-3-methylglutaryl-CoA reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog antibody, 3-hydroxy-3-methylglutaryl-Coenzyme A reductase antibody, HMG Coenzyme A reductase antibody, 3-hydroxy-3-methylglutaryl-CoA reductase b antibody, HMGCR antibody, hmgcr.L antibody, Hmgcr antibody, hmgcrb antibody
- Background
- HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.,HMGCR,LDLCQ3,HMGCR,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,Cholesterol Metabolism,AMPK Signaling Pathway,Cardiovascular,Heart,Lipids,Cardiovascular diseases,Heart disease,HMGCR
- Molecular Weight
- 92 kDa/97 kDa/99 kDa
- Gene ID
- 3156
- UniProt
- P04035
- Pathways
- AMPK Signaling, Negative Regulation of Hormone Secretion, Regulation of Lipid Metabolism by PPARalpha
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