IGHM antibody (AA 310-452)
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- Target See all IGHM products
- IGHM (Immunoglobulin Heavy Constant mu (IGHM))
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Binding Specificity
- AA 310-452
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This IGHM antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunocytochemistry (ICC), Neutralization (Neut)
- Purification
- purified
- Immunogen
- Purified recombinant fragment of human IGHM (AA: 310-452) expressed in E. coli.
- Clone
- 8B9D3
- Isotype
- IgG1
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anti-Immunoglobulin Heavy Constant mu (IGHM) antibody
IGHM Reactivity: Human IHC, WB Host: Rabbit Monoclonal unconjugated
anti-Immunoglobulin Heavy Constant mu (IGHM) antibodyIGHM Reactivity: Human IHC, StM, ISt Host: Rabbit Monoclonal IGHM-3776R unconjugated Recombinant Antibody
anti-Immunoglobulin Heavy Constant mu (IGHM) antibodyIGHM Reactivity: Human IHC, WB, StM, FACS, IF Host: Mouse Monoclonal IM373 unconjugated
anti-Immunoglobulin Heavy Constant mu (IGHM) (AA 45-178) antibodyIGHM Reactivity: Human IHC, WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Immunoglobulin Heavy Constant mu (IGHM) (AA 103-131), (N-Term) antibodyIGHM Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB18275 unconjugated
anti-Immunoglobulin Heavy Constant mu (IGHM) antibodyIGHM Reactivity: Human IHC, StM Host: Rabbit Monoclonal IGHM-3135R unconjugated Recombinant Antibody
anti-Immunoglobulin Heavy Constant mu (IGHM) antibodyIGHM Reactivity: Human IHC, StM, FACS, IF, ELISA, Coat Host: Mouse Monoclonal rIGHM-1623 unconjugated Recombinant Antibody
anti-Immunoglobulin Heavy Constant mu (IGHM) antibodyIGHM Reactivity: Human IHC, StM Host: Mouse Monoclonal rIM373 unconjugated Recombinant Antibody
anti-Immunoglobulin Heavy Constant mu (IGHM) (AA 1-489) antibodyIGHM Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Immunoglobulin Heavy Constant mu (IGHM) (AA 103-131) antibodyIGHM Reactivity: Human IHC, WB, ELISA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- ELISA: 1:10000, WB: 1:200 - 1:500, ICC: N/A, FCM: 1:200 - 1:400, IHC: 1:200 - 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- 4°C, -20°C for long term storage
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- Target
- IGHM (Immunoglobulin Heavy Constant mu (IGHM))
- Alternative Name
- IGHM (IGHM Products)
- Synonyms
- AI326478 antibody, Igh-6 antibody, Igh-M antibody, Igh6 antibody, Igm antibody, muH antibody, ighm1 antibody, wu:fj14a08 antibody, zgc:101769 antibody, AGM1 antibody, MU antibody, VH antibody, immunoglobulin heavy constant mu antibody, Ighm antibody, ighm antibody, IGHM antibody
- Background
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Description: Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD, MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).
Aliases: MU, VH, AGM1
- Molecular Weight
- 49.3 kDa
- Gene ID
- 3507
- HGNC
- 3507
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