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IL1RN antibody

Name: IL1RN antibody
Brand: antibodies-online
SKU: ABIN2856394
Price: 609.18 USD
Availability: InStock

IL1RN Reactivity: Human WB, ICC, IF, IHC (p) Host: Rabbit Polyclonal unconjugated

WB of IL-1-Ra of total plasma protein in a native, gradient gel under non-reducing conditions of patient MIS-C-I at presentation with acute inflammation and seropositive for IL-1-Ra-Abs of IgG class and 7 months later without IL-1-Ra-Abs.

ICC/IF Image Immunofluorescence analysis of methanol-fixed HeLa, using IL1ra antagonist , antibody at 1:200 dilution.

WB Image IL1 Receptor antagonist antibody detects IL1RN protein by Western blot analysis.

IHC-P Image Immunohistochemical analysis of paraffin-embedded PC3 xenograft, using IL1 Receptor antagonist, antibody at 1:500 dilution.

IHC

6 images

(1 reference)

Catalog No. ABIN2856394

Datasheet as PDF

Target See all IL1RN Antibodies

IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))
Reactivity
76

34

16

9

9

8

7

4

4

3
Human
Host
94

33

5

3

1

1
Rabbit
Compatible Secondaries
Clonality
102

35
Polyclonal
Conjugate
67

28

18

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1
This IL1RN antibody is un-conjugated
Application
113

52

37

24

23

21

18

16

13

13

7

6

6

3

2

2

1

1

1

1
Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity

Human, Mouse, Rat

Characteristics

Rabbit Polyclonal antibody to IL1 Receptor antagonist (interleukin 1 receptor antagonist)
IL1 Receptor antagonist antibody

Purification

Purified by antigen-affinity chromatography.

Immunogen

Recombinant protein encompassing a sequence within the center region of human IL1 Receptor antagonist. The exact sequence is proprietary.

Isotype

IgG
anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 26-177) antibody
IL1RN Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 26-177) antibody
IL1RN Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C1 unconjugated

anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 147-177), (C-Term) antibody
IL1RN Reactivity: Human WB, IF, FACS Host: Rabbit Polyclonal RB18902 unconjugated

anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 100-129) antibody
IL1RN Reactivity: Human WB, IF, FACS, IHC (p) Host: Rabbit Polyclonal RB18901 unconjugated

anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 1-159) antibody
IL1RN Reactivity: Human WB, ELISA, IP Host: Mouse Monoclonal 1H5 unconjugated

anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 27-178) antibody
IL1RN Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 26-177) antibody
IL1RN Reactivity: Rabbit WB, IHC, IP, ICC Host: Guinea Pig Polyclonal unconjugated

anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 22-235) antibody
IL1RN Reactivity: Human WB, ELISA, IF Host: Rabbit Polyclonal unconjugated

anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 22-230) antibody
IL1RN Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated

anti-Interleukin 1 Receptor Antagonist (IL1RN) (AA 26-177) antibody
IL1RN Reactivity: Human WB, IHC, IP, ICC Host: Mouse Monoclonal C7 unconjugated

Application Notes

WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Comment

Positive Control: Neuro2A whole , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , PC-12
Validation: Orthogonal

Restrictions

For Research Use only
Format

Liquid

Concentration

0.86 mg/mL

Buffer

1XPBS ( pH 7), 20 % Glycerol, 0.025 % ProClin 300

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C,-20 °C

Storage Comment

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
Pfeifer, Thurner, Kessel, Fadle, Kheiroddin, Regitz, Hoffmann, Kos, Preuss, Fischer, Roemer, Lohse, Heyne, Detemple, Fedlmeier, Juenger, Sauer, Meyer, Rohrer, Wittkowski, Becker, Masjosthusmann, Bals et al.: "Autoantibodies against interleukin-1 receptor antagonist in multisystem inflammatory syndrome in children: a multicentre, retrospective, cohort study. ..." in: The Lancet. Rheumatology, Vol. 4, Issue 5, pp. e329-e337, (2022) (PubMed).
Target

IL1RN (Interleukin 1 Receptor Antagonist (IL1RN))

Alternative Name

interleukin 1 receptor antagonist (IL1RN Products)

Synonyms

DIRA antibody, ICIL-1RA antibody, IL-1RN antibody, IL-1ra antibody, IL-1ra3 antibody, IL1F3 antibody, IL1RA antibody, IRAP antibody, MVCD4 antibody, IRAP1 antibody, IL1RN antibody, IL-1RA antibody, F630041P17Rik antibody, interleukin 1 receptor antagonist antibody, interleukin 1 receptor antagonist-like antibody, IL1RN antibody, Il1rn antibody, IL1RNL antibody

Background

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Cellular Localization: Isoform 1: Secreted , Isoform 2: Cytoplasm , Isoform 3: Cytoplasm , Isoform 4: Cytoplasm

Molecular Weight

20 kDa

Gene ID

3557

UniProt

P18510

Pathways

NF-kappaB Signaling, Hormone Transport, Cancer Immune Checkpoints