INSIG1 antibody (AA 1-87)
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- Target See all INSIG1 Antibodies
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
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Binding Specificity
- AA 1-87
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This INSIG1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Insulin-induced gene 1 protein (1-87AA)
- Isotype
- IgG
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anti-Insulin Induced Gene 1 (INSIG1) (Internal Region) antibody
INSIG1 Reactivity: Human, Mouse WB, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 36-63), (N-Term) antibodyINSIG1 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB21689 unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 63-112) antibodyINSIG1 Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Goat, Guinea Pig, Dog, Pig, Monkey, Hamster, Xenopus laevis, Bat, Chicken WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 1-100) antibodyINSIG1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Goat, Guinea Pig, Sheep, Dog, Zebrafish (Danio rerio) WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (AA 71-120) antibodyINSIG1 Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Goat, Sheep, Pig, Hamster, Xenopus laevis WB Host: Rabbit Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (C-Term) antibodyINSIG1 Reactivity: Human, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (C-Term) antibodyINSIG1 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-Insulin Induced Gene 1 (INSIG1) (Middle Region) antibodyINSIG1 Reactivity: Human, Mouse, Rat, Horse, Rabbit, Cow, Goat, Guinea Pig, Sheep, Dog, Pig, Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- INSIG1 (Insulin Induced Gene 1 (INSIG1))
- Alternative Name
- INSIG1 (INSIG1 Products)
- Synonyms
- cl-6 antibody, cl6 antibody, CL-6 antibody, CL6 antibody, fb55a03 antibody, fi35b10 antibody, wu:fb55a03 antibody, wu:fi35b10 antibody, zgc:55439 antibody, 1810013C12Rik antibody, Insig-1 antibody, INSIG-1 antibody, insulin induced gene 1 antibody, insulin induced gene 1 L homeolog antibody, INSIG1 antibody, insig1 antibody, insig1.L antibody, Insig1 antibody
- Background
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Background: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
Aliases: CL 6 antibody, CL6 antibody, INSI1_HUMAN antibody, INSIG 1 antibody, INSIG 1 membrane protein antibody, INSIG-1 antibody, insig1 antibody, INSIG1 membrane protein antibody, Insulin induced gene 1 antibody, Insulin induced gene 1 protein antibody, Insulin-induced gene 1 protein antibody, MGC1405 antibody
- UniProt
- O15503
- Pathways
- ER-Nucleus Signaling
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