ITPR1 antibody (AA 2411-2758)
(1 reference)-
- Target See all ITPR1 Antibodies
- ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))
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Binding Specificity
- AA 2411-2758
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ITPR1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purpose
- Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 1(ITPR1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
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Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 1(ITPR1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: inositol 1,4,5-trisphosphate receptor, type 1
Protein Name: Inositol 1,4,5-trisphosphate receptor type 1 - Purification
- Immunogen affinity purified.
- Immunogen
- E.coli-derived human IP3 receptor recombinant protein (Position: A2411-A2758). Human IP3 receptor shares 98% and 97% amino acid (aa) sequences identity with mouse and rat IP3 receptor, respectively.
- Isotype
- IgG
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anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (AA 1707-1966) antibody
ITPR1 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (AA 2731-2749) antibodyITPR1 Reactivity: Human, Mouse, Rat, Cow IHC, WB Host: Rabbit Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) antibodyITPR1 Reactivity: Human, Mouse, Rat ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (AA 1892-1911) antibodyITPR1 Reactivity: Human, Mouse, Rat, Cow, Monkey IHC, WB, IP, IHC (p), ICC, IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (pSer1764) antibodyITPR1 Reactivity: Human ELISA, IHC, WB Host: Rabbit Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (pSer1756), (pSer1764) antibodyITPR1 Reactivity: Human, Mouse, Rat ELISA, WB, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) antibodyITPR1 Reactivity: Human, Mouse, Rat ELISA, WB Host: Rabbit Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (pSer1764) antibodyITPR1 Reactivity: Human, Mouse, Rat ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (AA 2470-2577) antibodyITPR1 Reactivity: Human ELISA, WB Host: Mouse Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) antibodyITPR1 Reactivity: Human, Mouse, Rat IF Host: Rabbit Polyclonal unconjugated
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- Application Notes
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for IP3 receptor is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." in: PLoS ONE, Vol. 8, Issue 2, pp. e55839, (2013) (PubMed).
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: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." in: PLoS ONE, Vol. 8, Issue 2, pp. e55839, (2013) (PubMed).
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- Target
- ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))
- Alternative Name
- ITPR1 (ITPR1 Products)
- Synonyms
- D6Pas2 antibody, ENSMUSG00000072853 antibody, Gm10429 antibody, IP3R1 antibody, InsP3R antibody, Ip3r antibody, Itpr-1 antibody, P400 antibody, Pcp-1 antibody, Pcp1 antibody, opt antibody, I145TR antibody, InsP3R1 antibody, INSP3R1 antibody, IP3R antibody, SCA15 antibody, SCA16 antibody, SCA29 antibody, inositol 1,4,5-trisphosphate receptor type 1 antibody, inositol 1,4,5-trisphosphate receptor 1 antibody, inositol 1,4,5-trisphosphate receptor, type 1 antibody, ITPR1 antibody, Itpr1 antibody
- Background
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Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. The ITPR1 gene encodes the inositol 1,4,5-triphosphate(IP3) receptor, an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.
Synonyms: 4 antibody|5-trisphosphate receptor antibody|5-trisphosphate receptor type 1 antibody|DKFZp313E1334 antibody|DKFZp313N1434 antibody|inositol 1 4 5 triphosphate receptor type 1 antibody|Inositol 1 4 5 trisphosphate Receptor Type 1 antibody|Inositol 1 antibody|Inositol 145-trisphosphate Receptor Type 1 antibody|InsP3R1 antibody|IP3 antibody|IP3 receptor antibody|IP3 receptor isoform 1 antibody|IP3R 1 antibody|IP3R antibody|IP3R1 antibody|ITPR 1 antibody|Itpr1 antibody|ITPR1_HUMAN antibody|SCA15 antibody|SCA16 antibody|SCA29 antibody|Type 1 inositol 1 4 5 trisphosphate receptor antibody|Type 1 inositol 1 antibody|Type 1 InsP3 receptor antibody - Gene ID
- 3708
- UniProt
- Q14643
- Pathways
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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