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Kv1.4 antibody (C-Term)

KCNA4 Reactivity: Human WB Host: Rabbit Polyclonal RB41939 unconjugated
Catalog No. ABIN1881472
  • Target See all Kv1.4 (KCNA4) Antibodies
    Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))
    Binding Specificity
    • 15
    • 13
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 591-619, C-Term
    Reactivity
    • 40
    • 9
    • 7
    • 1
    • 1
    • 1
    Human
    Host
    • 41
    • 2
    Rabbit
    Clonality
    • 42
    • 1
    Polyclonal
    Conjugate
    • 19
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Kv1.4 antibody is un-conjugated
    Application
    • 28
    • 19
    • 13
    • 13
    • 4
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Predicted Reactivity
    B, M, Rat
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This KCNA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 591-619 amino acids from the C-terminal region of human KCNA4.
    Clone
    RB41939
    Isotype
    Ig Fraction
    Top Product
    Discover our top product KCNA4 Primary Antibody
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Expiry Date
    6 months
  • Schwetz, Norring, Bennett: "N-glycans modulate K(v)1.5 gating but have no effect on K(v)1.4 gating." in: Biochimica et biophysica acta, Vol. 1798, Issue 3, pp. 367-75, (2010) (PubMed).

    Lee, Lee, Choi, Yoon, Pyo, Shin, Choi, Lim, Rhim, Won, Lim, Choe, Kim, Kim, Nah: "Ginsenoside Rg3 inhibits human Kv1.4 channel currents by interacting with the Lys531 residue." in: Molecular pharmacology, Vol. 73, Issue 3, pp. 619-26, (2008) (PubMed).

    Mckeown, Burnham, Hodson, Jones et al.: "Identification of an evolutionarily conserved extracellular threonine residue critical for surface expression and its potential coupling of adjacent voltage-sensing and gating domains in..." in: The Journal of biological chemistry, Vol. 283, Issue 44, pp. 30421-32, (2008) (PubMed).

  • Target
    Kv1.4 (KCNA4) (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, Member 4 (KCNA4))
    Alternative Name
    KCNA4 (KCNA4 Products)
    Synonyms
    KV1.4 antibody, KCNA4 antibody, Kv1.4 antibody, DKFZp459N0126 antibody, KCHAN antibody, Kv4 antibody, RHK1 antibody, RK3 antibody, HBK4 antibody, HK1 antibody, HPCN2 antibody, HUKII antibody, KCNA4L antibody, KCNA8 antibody, PCN2 antibody, potassium voltage-gated channel subfamily A member 4 antibody, potassium voltage-gated channel subfamily A member 4 S homeolog antibody, potassium voltage-gated channel, shaker-related subfamily, member 4 antibody, KCNA4 antibody, LOC100622932 antibody, kcna4.S antibody, Kcna4 antibody
    Background
    Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.
    Molecular Weight
    73257
    NCBI Accession
    NP_002224
    UniProt
    P22459
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