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MSH2 antibody (N-Term)

Name: MSH2 antibody (N-Term)
SKU: ABIN2776761
Price: 472.77 USD
Availability: InStock

MSH2 Reactivity: Human, Mouse, Rat, Dog, Guinea Pig, Zebrafish (Danio rerio), Horse, Rabbit, Cow WB, IHC Host: Rabbit Polyclonal unconjugated

WB Suggested Anti-MSH2 Antibody Titration: 0.

Sample Type: Human KidneyPrimary Dilution: 1ug/mL

IHC

2 images

(1 reference)

Catalog No. ABIN2776761

Datasheet as PDF

Target See all MSH2 Antibodies

MSH2 (Mismatch Repair Protein 2 (MSH2))
Binding Specificity
15

8

8

7

7

6

6

4

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
Reactivity
79

40

18

6

4

4

3

3

2

2

2

2

2

1

1

1
Human, Mouse, Rat, Dog, Guinea Pig, Zebrafish (Danio rerio), Horse, Rabbit, Cow
Host
75

18

1
Rabbit
Compatible Secondaries
Clonality
71

24
Polyclonal
Conjugate
60

5

5

4

2

2

2

2

2

2

2

2

1

1

1

1

1
This MSH2 antibody is un-conjugated
Application
59

37

28

22

19

14

13

12

12

9

7

4

3

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

Sequence

GNKASKENDW YLAYKASPGN LSQFEDILFG NNDMSASIGV VGVKMSAVDG

Predicted Reactivity

Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Characteristics

This is a rabbit polyclonal antibody against MSH2. It was validated on Western Blot using a cell lysate as a positive control.

Purification

Affinity Purified

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human MSH2

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MSH2 Reactivity: Human WB, IHC, FACS, StM Host: Mouse Monoclonal MSH2-2622 unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 1-300) antibody
MSH2 Reactivity: Human WB, IF, IP Host: Rabbit Polyclonal unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 1-934) antibody
MSH2 Reactivity: Human WB, IF, PLA Host: Rabbit Polyclonal unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 337-583) antibody
MSH2 Reactivity: Human, Mouse, Rat WB, IHC (p), ICC Host: Rabbit Polyclonal unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 442-586) antibody
MSH2 Reactivity: Human WB, ELISA, FACS Host: Mouse Monoclonal 4F10D6 unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 835-934) antibody
MSH2 Reactivity: Human WB, ELISA, PLA Host: Mouse Monoclonal 4B2 unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 224-313) antibody
MSH2 Reactivity: Human IHC, StM Host: Mouse Monoclonal SYP-3551 unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 637-665) antibody
MSH2 Reactivity: Human WB, ELISA, IF, FACS Host: Rabbit Polyclonal unconjugated

anti-Mismatch Repair Protein 2 (MSH2) (AA 2-254) antibody
MSH2 Reactivity: Human WB, ELISA, IHC, IP Host: Rabbit Polyclonal unconjugated

Application Notes

Optimal working dilutions should be determined experimentally by the investigator.

Comment

Antigen size: 934 AA

Restrictions

For Research Use only
Format

Liquid

Concentration

Lot specific

Buffer

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice

Avoid repeated freeze-thaw cycles.

Storage

-20 °C

Storage Comment

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Wedrén, Lovmar, Humphreys, Magnusson, Melhus, Syvänen, Kindmark, Landegren, Fermér, Stiger, Persson, Baron, Weiderpass: "Estrogen receptor alpha gene polymorphism and endometrial cancer risk--a case-control study." in: BMC cancer, Vol. 8, pp. 322, (2009) (PubMed).
Target

MSH2 (Mismatch Repair Protein 2 (MSH2))

Alternative Name

MSH2 (MSH2 Products)

Synonyms

COCA1 antibody, FCC1 antibody, HNPCC antibody, HNPCC1 antibody, LCFS2 antibody, AI788990 antibody, wu:fc06b02 antibody, wu:fc13e09 antibody, zgc:55333 antibody, ATMSH2 antibody, MUTS homolog 2 antibody, msh2 antibody, mutS homolog 2 antibody, mutS homolog 2 (E. coli) antibody, MUTS homolog 2 antibody, mutS homolog 2 L homeolog antibody, MutS protein homolog 2 antibody, MSH2 antibody, Msh2 antibody, msh2 antibody, msh2.L antibody

Background

MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. MSH2 was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: COCA1, FCC1, HNPCC, HNPCC1, LCFS2
Protein Interaction Partner: ESR1, BRCA1, SUMO2, RPA3, RPA2, RPA1, REV1, POLK, DPYSL3, ATP6V1B2, CUL2, XRCC5, SUPT5H, STAT3, ST13, PDE3A, NRD1, JUP, XRCC6, SEC23A, HDAC6, PCNA, MSH3, MSH6, ERCC4, ERCC1, gag-pol, UBC, SUPT16H, SEPT9, SRSF10, SRSF11, SART1, SMARCA5, TOP2B, SRSF7, SRSF5
Protein Size: 934

Molecular Weight

105 kDa

Gene ID

4436

NCBI Accession

NM_000251, NP_000242

UniProt

P43246

Pathways

DNA Damage Repair, Production of Molecular Mediator of Immune Response