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Activating Transcription Factor 3 (ATF3) (Middle Region) Peptide

ATF3 Reactivity: Human Host: Synthetic BP, WB
Catalog No. ABIN973548
  • Target See all ATF3 products
    ATF3 (Activating Transcription Factor 3 (ATF3))
    Protein Region
    Middle Region
    Origin
    Human
    Source
    • 2
    Synthetic
    Application
    Blocking Peptide (BP), Western Blotting (WB)
    Characteristics
    This is a synthetic peptide designed for use in combination with anti-ATF3 antibody (Catalog #: ARP36556_P050). It may block above mentioned antibody from binding to its target protein in western blot and/or immunohistochecmistry under proper experimental settings. There is no guarantee for its use in other applications.
    Purification
    Purified
  • Application Notes
    Each Investigator should determine their own optimal working dilution for specific applications.
    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 100 μL of sterile PBS. Final peptide concentration is 1 mg/mL in PBS.
    Concentration
    1 mg/mL
    Buffer
    Final peptide concentration is 1 mg/mL in PBS.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
  • Target
    ATF3 (Activating Transcription Factor 3 (ATF3))
    Synonyms
    zgc:55526 Peptide, ATF3 Peptide, LRG-21 Peptide, LRF-1 Peptide, LRFI Peptide, atf-3 Peptide, activating transcription factor 3 Peptide, activating transcription factor 3 L homeolog Peptide, atf3 Peptide, ATF3 Peptide, Atf3 Peptide, atf3.L Peptide
    Background
    This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF3 represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

    Alias Symbols: -

    Protein Interaction Partner: ATF3,TP53,ATF3,BATF3,C1orf103,DDIT3,FGFR3,IGSF21,JUN,JUND,NFKB1,NUF2,SMAD3,TP53,ATF4,C1orf103,DDIT3,FGFR3,IGSF21,JUN,JUND,SMAD3,TP53

    Protein Size: 181
    Molecular Weight
    20 kDa
    Gene ID
    467
    NCBI Accession
    NM_001674, NP_001665
    UniProt
    P18847
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