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PARK7/DJ1 antibody (C-Term)

Name: PARK7/DJ1 antibody (C-Term)
SKU: ABIN1881625
Price: 429 USD
Availability: InStock

PARK7 Reactivity: Zebrafish (Danio rerio) WB Host: Rabbit Polyclonal unconjugated

DANRE park7 Antibody (C-term) Azb10028b western blot analysis in zebra fish brain and muscle tissue lysates (35 μg/lane).

1 image

(2 references)

Catalog No. ABIN1881625

Datasheet as PDF

Target See all PARK7/DJ1 (PARK7) Antibodies

PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
Binding Specificity
21

16

10

7

5

5

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 120-149, C-Term
Reactivity
93

71

51

8

5

4

3

3

2

2

1

1

1

1

1
Zebrafish (Danio rerio)
Host
98

15

2

1
Rabbit
Compatible Secondaries
Clonality
93

23
Polyclonal
Conjugate
70

13

9

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1
This PARK7/DJ1 antibody is un-conjugated
Application
96

44

31

31

27

21

20

15

14

13

5

5

5

4

2

1

1

1
Western Blotting (WB)

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This DANRE park7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of DANRE park7.

Isotype

Ig Fraction

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Application Notes

WB: 1:1000

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C,-20 °C

Expiry Date

6 months
Bretaud, Allen, Ingham, Bandmann: "p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease." in: Journal of neurochemistry, Vol. 100, Issue 6, pp. 1626-35, (2007) (PubMed).

Bai, Mullett, Garver, Hinkle, Burton: "Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons." in: Brain research, Vol. 1113, Issue 1, pp. 33-44, (2006) (PubMed).
Target

PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Alternative Name

park7 (PARK7 Products)

Synonyms

DJ-1 antibody, DJ1 antibody, CAP1 antibody, Dj1 antibody, SP22 antibody, dj1 antibody, zgc:103725 antibody, park7b antibody, park7 antibody, park7a antibody, Parkinsonism associated deglycase antibody, Parkinson disease (autosomal recessive, early onset) 7 antibody, parkinson protein 7 antibody, parkinson protein 7 S homeolog antibody, parkinson protein 7 L homeolog antibody, PARK7 antibody, Park7 antibody, park7 antibody, park7.S antibody, park7.L antibody

Background

Protects cells against oxidative stress and cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone (By similarity). Protects dopaminergic neurons against cell death arising from oxidative stress and proteasome inhibition, probably by a TP53/p53-dependent mechanism.

Molecular Weight

19764

NCBI Accession

NP_001005938

UniProt

Q5XJ36

Pathways

Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport