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MYH11 antibody

MYH11 Reactivity: Human IHC, IF, WB Host: Rabbit Monoclonal unconjugated
Catalog No. ABIN7268745
  • Target See all MYH11 Antibodies
    MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))
    Reactivity
    • 40
    • 20
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    Human
    Host
    • 35
    • 8
    Rabbit
    Clonality
    • 23
    • 20
    Monoclonal
    Conjugate
    • 26
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    This MYH11 antibody is un-conjugated
    Application
    • 14
    • 12
    • 11
    • 8
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blotting (WB)
    Purpose
    SMMHC/MYH11 Rabbit mAb
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Monoclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    A synthesized peptide derived from human SMMHC/SMMHC/MYH11
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    MYH11 (Myosin Heavy Chain 11, Smooth Muscle (MYH11))
    Alternative Name
    MYH11 (MYH11 Products)
    Synonyms
    AV071570 antibody, SM1 antibody, SM2 antibody, smMHC antibody, AAT4 antibody, FAA4 antibody, SMHC antibody, SMMHC antibody, myosin antibody, myh11 antibody, myosin, heavy polypeptide 11, smooth muscle antibody, myosin heavy chain 11 antibody, myosin, heavy chain 11, smooth muscle antibody, myosin, heavy chain 11a, smooth muscle antibody, Myh11 antibody, MYH11 antibody, myh11a antibody
    Background
    The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],AAT4, FAA4, SMHC, SMMHC,Cardiovascular,Cardiovascular Markers,Cardiovascular Markers_Smooth Muscle Cells,Cell Biology & Developmental Biology,Cytoskeleton,Cytoskeleton_Motor Proteins,Heart,Heart_Contractility,Signal Transduction,Stem Cells,MYH11
    Molecular Weight
    250kDa
    Gene ID
    4629
    UniProt
    P35749
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