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NAIP antibody (AA 147-242)

Name: NAIP antibody (AA 147-242)
Brand: antibodies-online
SKU: ABIN7145194
Price: 328.9 USD
Availability: InStock

NAIP Reactivity: Human WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated

Western Blot Positive WB detected in: HepG2 whole cell lysate, A549 whole cell lysate, Hela whole cell lysate All lanes: NAIP antibody at 3.

IHC image of ABIN7145194 diluted at 1:200 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system.

IHC

Immunofluorescence staining of A549 cells with ABIN7145194 at 1:66, counter-stained with DAPI.

3 images

Catalog No. ABIN7145194

Datasheet as PDF

Target See all NAIP Antibodies

NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))
Binding Specificity
15

3

3

3

1

1

1

1

1

1
AA 147-242
Reactivity
31

4

2
Human
Host
31

1

1
Rabbit
Compatible Secondaries
Clonality
31

2
Polyclonal
Conjugate
16

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This NAIP antibody is un-conjugated
Application
26

13

13

13

7

4

4

3

3

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity

Human

Purification

>95%, Protein G purified

Immunogen

Recombinant Human Baculoviral IAP repeat-containing protein 1 protein (147-242AA)

Isotype

IgG
anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) antibody
NAIP Reactivity: Human WB, IHC Host: Rabbit Monoclonal unconjugated

anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) (AA 500-759) antibody
NAIP Reactivity: Mouse WB, IHC, ICC, IP Host: Rabbit Polyclonal unconjugated

anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) antibody
NAIP Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated

anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) (AA 923-1148) antibody
NAIP Reactivity: Human WB, IHC, ICC Host: Rabbit Polyclonal unconjugated

anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) (AA 1191-1240) antibody
NAIP Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated

anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) antibody
NAIP Reactivity: Rat WB Host: Rabbit Polyclonal unconjugated

anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) (AA 750-850) antibody
NAIP Reactivity: Human WB Host: Rabbit Polyclonal unconjugated

anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) (C-Term) antibody
NAIP Reactivity: Human WB, IF, EIA Host: Rabbit Polyclonal unconjugated

anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) (N-Term) antibody
Recent NAIP Reactivity: Human ELISA Host: Goat Polyclonal unconjugated

anti-NLR Family, Apoptosis Inhibitory Protein (NAIP) (AA 147-242) antibody (HRP)
NAIP Reactivity: Human ELISA Host: Rabbit Polyclonal HRP

Application Notes

Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions

For Research Use only
Format

Liquid

Buffer

Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C,-80 °C

Storage Comment

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target

NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Alternative Name

NAIP (NAIP Products)

Synonyms

BIRC1 antibody, NLRB1 antibody, psiNAIP antibody, AV364616 antibody, Birc1a antibody, D13Lsd1 antibody, Naip antibody, Naip-rs1 antibody, NLR family apoptosis inhibitory protein antibody, NLR family, apoptosis inhibitory protein 1 antibody, NAIP antibody, Naip1 antibody

Background

Background: \\\"Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at \\\'Asp-315\\\' and decreasing the rate of auto proteolysis at \\\'Asp-330\\\'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy. Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.\\\"
Aliases: Baculoviral IAP repeat containing 1 antibody, Baculoviral IAP repeat-containing protein 1 antibody, BIRC 1 antibody, BIRC1 antibody, BIRC1_HUMAN antibody, Birc1a antibody, FLJ42520 antibody, NAIP antibody, Naip1 antibody, Neuronal apoptosis inhibitory protein antibody, NLR family apoptosis inhibitory protein antibody, NLR family BIR domain containing 1 antibody, NLRB 1 antibody, NLRB1 antibody, Nucleotide binding oligomerization domain leucine rich repeat and BIR domain containing 1 antibody, Psi neuronal apoptosis inhibitory protein antibody, psiNAIP antibody, Similar to occludin antibody

UniProt

Q13075

Pathways

Apoptosis, Inflammasome