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TRPV3 antibody (AA 458-474)

TRPV3 Reactivity: Rat WB, IHC, IP, ICC, IF, AA Host: Mouse Monoclonal N15-39 (Formerly S15-39) unconjugated
Catalog No. ABIN863127
  • Target See all TRPV3 Antibodies
    TRPV3 (Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3))
    Binding Specificity
    • 24
    • 21
    • 13
    • 11
    • 9
    • 8
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    AA 458-474
    Reactivity
    • 58
    • 53
    • 32
    • 2
    Rat
    Host
    • 58
    • 38
    • 1
    Mouse
    Clonality
    • 59
    • 38
    Monoclonal
    Conjugate
    • 37
    • 9
    • 8
    • 8
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRPV3 antibody is un-conjugated
    Application
    • 83
    • 68
    • 37
    • 34
    • 28
    • 26
    • 21
    • 11
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunofluorescence (IF), Antibody Array (AA)
    Specificity
    Detects ~70 kDa.
    Cross-Reactivity
    Human, Mouse, Rat
    Purification
    Protein G Purified
    Immunogen
    Synthetic peptide amino acids 458-474 (cytoplasmic C-terminus) of rat TrpV3
    Clone
    N15-39 (Formerly S15-39)
    Isotype
    IgG2a
  • Application Notes
    • WB (1:1000)
    • IHC (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Comment

    1 μg/ml of ABIN863127 was sufficient for detection of TrpV3 in 10 μg of COS-1 cell lysate transiently transfected with TrpV3 by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    -20°C
  • Liebe, Liebe, Sponder, Mergler, Stumpff: "Effects of butyrate- on ruminal Ca2+ transport: evidence for the involvement of apically expressed TRPV3 and TRPV4 channels." in: Pflugers Archiv : European journal of physiology, Vol. 474, Issue 3, pp. 315-342, (2022) (PubMed).

    Manneck, Manz, Braun, Rosendahl, Stumpff: "The TRPA1 Agonist Cinnamaldehyde Induces the Secretion of HCO3- by the Porcine Colon." in: International journal of molecular sciences, Vol. 22, Issue 10, (2021) (PubMed).

    Liebe, Liebe, Sponder, Hedtrich, Stumpff: "Beyond Ca2+ signalling: the role of TRPV3 in the transport of NH4." in: Pflügers Archiv : European journal of physiology, (2021) (PubMed).

    Liebe, Liebe, Kaessmeyer, Sponder, Stumpff: "The TRPV3 channel of the bovine rumen: localization and functional characterization of a protein relevant for ruminal ammonia transport." in: Pflügers Archiv : European journal of physiology, (2020) (PubMed).

  • Target
    TRPV3 (Transient Receptor Potential Cation Channel, Subfamily V, Member 3 (TRPV3))
    Alternative Name
    TRPV3 (TRPV3 Products)
    Synonyms
    OLMS antibody, VRL3 antibody, 1110036I10Rik antibody, AI644701 antibody, Nh antibody, transient receptor potential cation channel subfamily V member 3 antibody, transient receptor potential cation channel, subfamily V, member 3 antibody, TRPV3 antibody, Trpv3 antibody
    Background
    The TRPV3 protein belongs to a family of non-selective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermo sensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. The gene lies in close proximity to another family member (TRPV1) gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels (1, 2).
    Gene ID
    497948
    NCBI Accession
    NP_001020928
    UniProt
    Q4QYD9
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