SH2D1A antibody (C-Term)
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- Target See all SH2D1A Antibodies
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
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Binding Specificity
- C-Term
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Reactivity
- Human, Rat, Pig, Cow, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SH2D1A antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
- Predicted Reactivity
- Cow: 86%, Horse: 92%, Human: 100%, Pig: 100%, Rat: 93%
- Characteristics
- This is a rabbit polyclonal antibody against SH2D1A. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A
- Top Product
- Discover our top product SH2D1A Primary Antibody
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anti-SH2 Domain Containing 1A (SH2D1A) (AA 1-128) antibody
SH2D1A Reactivity: Human WB, ELISA Host: Mouse Monoclonal 1C9 unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 1-128) antibodySH2D1A Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 11-124) antibodySH2D1A Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 85-114), (C-Term) antibodySH2D1A Reactivity: Human WB Host: Rabbit Polyclonal RB41923 unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (C-Term) antibodySH2D1A Reactivity: Human, Monkey, Rabbit, Bat WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) antibodySH2D1A Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 18-115) antibodySH2D1A Reactivity: Mouse WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (Internal Region) antibodyVerified SH2D1A Reactivity: Human WB, ELISA, IP Host: Goat Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) (AA 1-128) antibodySH2D1A Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-SH2 Domain Containing 1A (SH2D1A) antibodySH2D1A Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 128 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- Alternative Name
- SH2D1A (SH2D1A Products)
- Synonyms
- DSHP antibody, EBVS antibody, IMD5 antibody, LYP antibody, MTCP1 antibody, SAP antibody, SAP/SH2D1A antibody, XLP antibody, XLPD antibody, RGD1562408 antibody, Gm686 antibody, SH2D1A antibody, SH2 domain containing 1A antibody, SH2D1A antibody, Sh2d1a antibody
- Background
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SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Alias Symbols: DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD, SAP/SH2D1A
Protein Interaction Partner: LHX4, TNK2, UBC, LYN, MAPK11, MAPK1, ERBB3, EGFR, MAPK14, CD244, ELAVL1, SLAMF7, SLAMF6, ARHGEF7, CD84, SLAMF1, DOK1, FYB, LY9, ARHGEF6, LCK, FYN, GRB2,
Protein Size: 128 - Molecular Weight
- 14 kDa
- Gene ID
- 4068
- NCBI Accession
- NM_002351, NP_002342
- UniProt
- O60880
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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