FURIN antibody (AA 120-370)
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- Target See all FURIN Antibodies
- FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
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Binding Specificity
- AA 120-370
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FURIN antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- Sequence
- QQWYLSGVTQ RDLNVKAAWA QGYTGHGIVV SILDDGIEKN HPDLAGNYDP GASFDVNDQD PDPQPRYTQM NDNRHGTRCA GEVAAVANNG VCGVGVAYNA RIGGVRMLDG EVTDAVEARS LGLNPNHIHI YSASWGPEDD GKTVDGPARL AEEAFFRGVS QGRGGLGSIF VWASGNGGRE HDSCNCDGYT NSIYTLSISS ATQFGNVPWY SEACSSTLAT TYSSGNQNEK QIVTTDLRQK CTESHTGTSA S
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 120-370 of human Furin (NP_002560.1).
- Isotype
- IgG
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anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 587-748) antibody
FURIN Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 418-573) antibodyFURIN Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (Internal Region) antibodyVerified FURIN Reactivity: Human ELISA, IF Host: Goat Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 385-500) antibodyFURIN Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 520-701) antibodyFURIN Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 578-734) antibodyFURIN Reactivity: Mouse WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) antibodyFURIN Reactivity: Human WB, IHC, ELISA Host: Rabbit Monoclonal 1C3 unconjugated Recombinant Antibody
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 553-565) antibodyFURIN Reactivity: Human, Mouse, Rat, Cow, Dog, Pig ELISA, IHC (p) Host: Goat Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (C-Term) antibodyFURIN Reactivity: Human, Mouse, Rat, Cow, Dog, Pig WB, ELISA Host: Goat Polyclonal unconjugated
anti-Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN) (AA 105-221) antibodyFURIN Reactivity: Human WB, IHC, ICC Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- FURIN (Furin (Paired Basic Amino Acid Cleaving Enzyme) (FURIN))
- Alternative Name
- FURIN (FURIN Products)
- Background
- This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants.,FURIN,FUR,PACE,PCSK3,SPC1,furin,Signal Transduction,Cell Biology & Developmental Biology,Cell Adhesion,Cytoskeleton,Ubiquitin,Notch Signaling Pathway,Endocrine & Metabolism,FURIN
- Molecular Weight
- 86 kDa
- Gene ID
- 5045
- UniProt
- P09958
- Pathways
- Notch Signaling, Neurotrophin Signaling Pathway
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