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CHCHD2 antibody (AA 75-145)

KO Validated CHCHD2 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7266448
  • Target See all CHCHD2 products
    CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))
    Binding Specificity
    • 7
    • 7
    • 7
    • 6
    • 1
    • 1
    AA 75-145
    Reactivity
    • 19
    • 5
    • 3
    Human
    Host
    • 20
    Rabbit
    Clonality
    • 20
    Polyclonal
    Conjugate
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    This CHCHD2 antibody is un-conjugated
    Application
    • 20
    • 15
    • 14
    • 12
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purpose
    [KO Validated] CHCHD2 Rabbit pAb
    Sequence
    TLGHAITGGF SGGSNAEPAR PDITYQEPQG TQPAQQQQPC LYEIKQFLEC AQNQGDIKLC EGFNEVLKQC R
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Grade
    KO Validated
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 75-145 of human CHCHD2 (NP_057223.1).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CHCHD2 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 2 (CHCHD2))
    Alternative Name
    CHCHD2 (CHCHD2 Products)
    Synonyms
    AL033347 antibody, Etohi6 antibody, C7orf17 antibody, CHCHD9 antibody, chchd2 antibody, coiled-coil-helix-coiled-coil-helix domain containing 2 antibody, coiled-coil-helix-coiled-coil-helix domain containing 2 L homeolog antibody, Chchd2 antibody, CHCHD2 antibody, chchd2.L antibody
    Background
    The protein encoded by this gene belongs to a class of eukaryotic CX(9)C proteins characterized by four cysteine residues spaced ten amino acids apart from one another. These residues form disulfide linkages that define a CHCH fold. In response to stress, the protein translocates from the mitochondrial intermembrane space to the nucleus where it binds to a highly conserved 13 nucleotide oxygen responsive element in the promoter of cytochrome oxidase 4I2, a subunit of the terminal enzyme of the electron transport chain. In concert with recombination signal sequence-binding protein J, binding of this protein activates the oxygen responsive element at four percent oxygen. In addition, it has been shown that this protein is a negative regulator of mitochondria-mediated apoptosis. In response to apoptotic stimuli, mitochondrial levels of this protein decrease, allowing BCL2-associated X protein to oligomerize and activate the caspase cascade. Pseudogenes of this gene are found on multiple chromosomes. Alternative splicing results in multiple transcript variants.,CHCHD2,C7orf17,MNRR1,NS2TP,PARK22,Cell Biology & Developmental Biology,CHCHD2
    Molecular Weight
    15kDa
    Gene ID
    51142
    UniProt
    Q9Y6H1
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