PTRH2 antibody (AA 40-179)
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- Target See all PTRH2 Antibodies
- PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
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Binding Specificity
- AA 40-179
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PTRH2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Sequence
- LPKSKTSKTH TDTESEASIL GDSGEYKMIL VVRNDLKMGK GKVAAQCSHA AVSAYKQIQR RNPEMLKQWE YCGQPKVVVK APDEETLIAL LAHAKMLGLT VSLIQDAGRT QIAPGSQTVL GIGPGPADLI DKVTGHLKLY
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 40-179 of human PTRH2 (NP_057161.1).
- Isotype
- IgG
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anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 42-178) antibody
PTRH2 Reactivity: Human WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 40-179) antibodyPTRH2 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 26-55), (N-Term) antibodyPTRH2 Reactivity: Human WB Host: Rabbit Polyclonal RB42733 unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 80-110) antibodyPTRH2 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB06095 unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (AA 100-149) antibodyPTRH2 Reactivity: Human, Cow, Dog, Guinea Pig, Horse, Monkey, Pig WB Host: Rabbit Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) antibodyPTRH2 Reactivity: Human, Mouse, Rat WB, IF, IC Host: Rabbit Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (N-Term) antibodyPTRH2 Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated
anti-Peptidyl-tRNA Hydrolase 2 (PTRH2) (Middle Region) antibodyPTRH2 Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:10 - 1:100
- Comment
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HIGH QUALITY
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
- Alternative Name
- PTRH2 (PTRH2 Products)
- Synonyms
- BIT1 antibody, PTH2 antibody, A230072I16Rik antibody, Bit1 antibody, CGI-147 antibody, wu:fj09f02 antibody, zgc:109954 antibody, RGD1306819 antibody, peptidyl-tRNA hydrolase 2 antibody, ptrh2 antibody, CC1G_10259 antibody, ANI_1_1036184 antibody, AOR_1_2082154 antibody, PTRH2 antibody, Ptrh2 antibody
- Background
- The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms.,PTRH2,BIT1,CFAP37,CGI-147,IMNEPD,PTH,PTH 2,PTH2,Epigenetics & Nuclear Signaling,Cell Biology & Developmental Biology,Apoptosis,Cell Cycle,Endocrine & Metabolism,Mitochondrial metabolism,Mitochondrial markers,PTRH2
- Molecular Weight
- 19 kDa
- Gene ID
- 51651
- UniProt
- Q9Y3E5
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