CDK12 antibody (AA 80-290)
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- Target See all CDK12 (CRKRS) Antibodies
- CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))
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Binding Specificity
- AA 80-290
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CDK12 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purpose
- CDK12 Rabbit pAb
- Sequence
- SDTFSDDMAF KLDRRENDER RGSDRSDRLH KHRHHQHRRS RDLLKAKQTE KEKSQEVSSK SGSMKDRISG SSKRSNEETD DYGKAQVAKS SSKESRSSKL HKEKTRKERE LKSGHKDRSK SHRKRETPKS YKTVDSPKRR SRSPHRKWSD SSKQDDSPSG ASYGQDYDLS PSRSHTSSNY DSYKKSPGST SRRQSVSPPY KEPSAYQSST R
- Cross-Reactivity
- Human, Mouse, Rat
- Characteristics
- Polyclonal Antibodies
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein containing a sequence corresponding to amino acids 80-290 of human CDK12 (NP_057591.2).
- Isotype
- IgG
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anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (AA 1281-1380) antibody
CRKRS Reactivity: Human ELISA, WB, IF Host: Mouse Monoclonal 1H4 unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (AA 1281-1380) antibodyCRKRS Reactivity: Human ELISA, WB, IF, IHC (p) Host: Mouse Monoclonal 3C1 unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) antibodyCRKRS Reactivity: Human, Mouse, Rat ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (Internal Region) antibodyCRKRS Reactivity: Human, Dog, Monkey IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (AA 1281-1380) antibodyCRKRS Reactivity: Human ELISA, WB Host: Mouse Monoclonal 2F6 unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (AA 1309-1490) antibodyCRKRS Reactivity: Human ELISA, WB Host: Rabbit Polyclonal unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (C-Term) antibodyCRKRS Reactivity: Human, Rat ELISA, WB Host: Rabbit Polyclonal unconjugated
anti-Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS) (AA 1-30), (N-Term) antibodyCRKRS Reactivity: Human, Mouse WB Host: Rabbit Polyclonal RB3214 unconjugated
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- Application Notes
- WB,1:500 - 1:2000,IHC,1:50 - 1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- CDK12 (CRKRS) (Cdc2-Related Kinase, Arginine/serine-Rich (CRKRS))
- Alternative Name
- CDK12 (CRKRS Products)
- Synonyms
- AC017581 antibody, CG7597 antibody, Dmel\\CG7597 antibody, anon-WO0140519.165 antibody, cg7597 antibody, dCDK12 antibody, gi24668141 antibody, CRK7 antibody, CRKR antibody, CRKRS antibody, hCDK12 antibody, 1810022J16Rik antibody, AI646528 antibody, Crk7 antibody, Crkrs antibody, D11Ertd752e antibody, Pksc antibody, Cyclin-dependent kinase 12 antibody, cyclin dependent kinase 12 antibody, cyclin-dependent kinase 12 antibody, Cdk12 antibody, CDK12 antibody
- Background
- Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD of the large subunit of RNA polymerase II (POLR2A, thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.,CDK12,CRK7,CRKR,CRKRS,Cancer,Signal Transduction,Kinase,Tyrosine kinases,CDK12
- Molecular Weight
- 141kDa/163kDa/164kDa
- Gene ID
- 51755
- UniProt
- Q9NYV4
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