PIK3R1 antibody (pTyr607)
(5 references)-
- Target See all PIK3R1 (PI3K p85a) Antibodies
- PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
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Binding Specificity
- pTyr607
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Reactivity
- Human, Mouse, Rat, Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PIK3R1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Phospho-PI3-kinase p85- alpha (Tyr607) Antibody detects endogenous levels of PI3-kinase p85- alpha only when phosphorylated at Tyrosine 607
- Cross-Reactivity
- Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human PI3-kinase p85- alpha around the phosphorylation site of Tyrosine 607
- Isotype
- IgG
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anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 159-388) antibody
PI3K p85a Reactivity: Human, Mouse WB, ELISA, IHC, FACS, ICC Host: Mouse Monoclonal 6G10 unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 1-454) antibodyPI3K p85a Reactivity: Human WB, ELISA, IP, PLA Host: Mouse Monoclonal 3A10 unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 501-600) antibodyPI3K p85a Reactivity: Human, Mouse, Rat, Rabbit WB, ELISA, IHC (p), FACS, IF (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 1-30), (N-Term) antibodyPI3K p85a Reactivity: Human, Rat WB, IHC (p), IF, FACS Host: Rabbit Polyclonal RB11634 unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 159-388) antibodyPI3K p85a Reactivity: Human, Mouse WB, ELISA, IHC, FACS, IF/ICC Host: Mouse Monoclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (pTyr607) antibodyPI3K p85a Reactivity: Human, Mouse, Rat, Chicken WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (AA 15-180) antibodyPI3K p85a Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) (C-Term) antibodyPI3K p85a Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) antibodyPI3K p85a Reactivity: Mouse, Rat WB, IHC Host: Mouse Monoclonal 3B7 unconjugated
anti-Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a) antibodyPI3K p85a Reactivity: Mouse, Rat WB, IHC (p) Host: Mouse Monoclonal unconjugated
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200 ICC/IF 1:100-500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C.Stable for 12 months from date of receipt
- Expiry Date
- 12 months
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: "HBP induces the expression of monocyte chemoattractant protein-1 via the FAK/PI3K/AKT and p38 MAPK/NF-κB pathways in vascular endothelial cells." in: Cellular signalling, Vol. 43, pp. 85-94, (2018) (PubMed).
: "Biological functions of lung cancer cells are suppressed in co-culture with mesenchymal stem cells isolated from umbilical cord." in: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 1076-1080, (2018) (PubMed).
: "Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway." in: Marine drugs, Vol. 16, Issue 3, (2018) (PubMed).
: "Umbilical cord‑derived mesenchymal stem cells can inhibit the biological functions of melanoma A375 cells." in: Oncology reports, Vol. 40, Issue 1, pp. 511-517, (2018) (PubMed).
: "Prolyl hydroxylases positively regulated LPS-induced inflammation in human gingival fibroblasts via TLR4/MyD88-mediated AKT/NF-κB and MAPK pathways." in: Cell proliferation, pp. e12516, (2018) (PubMed).
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: "HBP induces the expression of monocyte chemoattractant protein-1 via the FAK/PI3K/AKT and p38 MAPK/NF-κB pathways in vascular endothelial cells." in: Cellular signalling, Vol. 43, pp. 85-94, (2018) (PubMed).
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- Target
- PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))
- Alternative Name
- PI3K p85 alpha (PI3K p85a Products)
- Synonyms
- PI3CG antibody, PI3K antibody, PI3Kgamma antibody, PIK3 antibody, AGM7 antibody, GRB1 antibody, p85 antibody, p85-ALPHA antibody, PI3KA antibody, AA414921 antibody, C530050K14 antibody, p50alpha antibody, p55alpha antibody, p85alpha antibody, wu:fb65b05 antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma antibody, phosphoinositide-3-kinase regulatory subunit 1 antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta antibody, phosphoinositide-3-kinase, regulatory subunit 1 (alpha) antibody, PIK3CG antibody, PIK3R1 antibody, Pik3r1 antibody, Pik3cb antibody, pik3r1 antibody
- Background
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Description: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).
Gene: PIK3R1
- Molecular Weight
- 80kDa
- Gene ID
- 5295
- UniProt
- P27986
- Pathways
- TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effect
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