IRAK4 antibody (pThr345)
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- Target See all IRAK4 Antibodies
- IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
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Binding Specificity
- pThr345
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Reactivity
- Human, Mouse, Rat, Cow, Pig, Dog
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This IRAK4 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human, Mouse, Rat
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic phosphopeptide derived from human IRAK4 around the phosphorylation site of Thr345
- Isotype
- IgG
- Top Product
- Discover our top product IRAK4 Primary Antibody
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anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) antibody
IRAK4 Reactivity: Human, Mouse, Monkey WB, ELISA, IHC, FACS Host: Mouse Monoclonal 2H9 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 189-427) antibodyIRAK4 Reactivity: Human WB, ELISA, IHC (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-220) antibodyIRAK4 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 5-36), (N-Term) antibodyIRAK4 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB2347 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (N-Term) antibodyVerified IRAK4 Reactivity: Human WB, ELISA, IHC, FACS, IF Host: Goat Polyclonal unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-130) antibodyIRAK4 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2D3 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 25-52), (N-Term) antibodyIRAK4 Reactivity: Human WB Host: Rabbit Polyclonal RB33094 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-130) antibodyIRAK4 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 1D4 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (pThr345) antibodyIRAK4 Reactivity: Human, Mouse, Cow, Dog WB, ELISA, IHC, IP, DB Host: Mouse Monoclonal A8A8 unconjugated
anti-Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (AA 1-220) antibodyIRAK4 Reactivity: Human WB, ELISA, IP Host: Rabbit Polyclonal unconjugated
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- Application Notes
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WB(1:100-500)
Optimal working dilution should be determined by the investigator. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C for 12 months.
- Expiry Date
- 12 months
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- Target
- IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
- Alternative Name
- IRAK4 (IRAK4 Products)
- Synonyms
- zgc:55553 antibody, IRAK4 antibody, ipd1 antibody, irak-4 antibody, ny-ran-64 antibody, ny-ren-64 antibody, ren64 antibody, irak4 antibody, IPD1 antibody, IRAK-4 antibody, NY-REN-64 antibody, REN64 antibody, 8430405M07Rik antibody, 9330209D03Rik antibody, interleukin 1 receptor associated kinase 4 antibody, interleukin-1 receptor-associated kinase 4 antibody, IRAK4 antibody, irak4 antibody, Irak4 antibody
- Background
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Synonyms: IPD1, REN64, IRAK-4, NY-REN-64, Interleukin-1 receptor-associated kinase 4, Renal carcinoma antigen NY-REN-64, IRAK4
Background: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
- Molecular Weight
- 51kDa
- Gene ID
- 51135
- UniProt
- Q9NWZ3
- Pathways
- NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
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