SOX18 antibody (Middle Region)
(3 references)-
- Target See all SOX18 Antibodies
- SOX18 (SRY (Sex Determining Region Y)-Box 18 (SOX18))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SOX18 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Sequence
- RTAPPAAPLA GLYYGTLGTP GPYPGPLSPP PEAPPLESAE PLGPAADLWA
- Predicted Reactivity
- Cow: 86%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against SOX18. It was validated on Western Blot and immunohistochemistry.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human SOX18
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anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 63-150) antibody
SOX18 Reactivity: Human WB, ELISA, IF Host: Mouse Monoclonal 1C4 unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 271-320) antibodySOX18 Reactivity: Human, Mouse WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 153-377) antibodySOX18 Reactivity: Rat WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 271-320) antibodySOX18 Reactivity: Human, Mouse, Rat, Cow, Guinea Pig, Pig, Hamster WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 63-150) antibodySOX18 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 192-241) antibodySOX18 Reactivity: Human, Mouse, Rat, Guinea Pig, Pig WB Host: Rabbit Polyclonal unconjugated
anti-SRY (Sex Determining Region Y)-Box 18 (SOX18) (AA 1-100) antibodySOX18 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 384 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity." in: The Journal of clinical investigation, Vol. 124, Issue 9, pp. 3960-74, (2014) (PubMed).
: "Endothelial ERK signaling controls lymphatic fate specification." in: The Journal of clinical investigation, Vol. 123, Issue 3, pp. 1202-15, (2013) (PubMed).
: "Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice." in: Cancer research, Vol. 72, Issue 12, pp. 3105-14, (2012) (PubMed).
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: "Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity." in: The Journal of clinical investigation, Vol. 124, Issue 9, pp. 3960-74, (2014) (PubMed).
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- Target
- SOX18 (SRY (Sex Determining Region Y)-Box 18 (SOX18))
- Alternative Name
- SOX18 (SOX18 Products)
- Synonyms
- HLTS antibody, AI385749 antibody, Ra antibody, Ragl antibody, sox18 antibody, xSox18alpha antibody, xSox18beta antibody, xsox18 antibody, SRY-box 18 antibody, SRY (sex determining region Y)-box 18 antibody, SRY box 18 antibody, SRY-box 18 S homeolog antibody, SRY-box 18 L homeolog antibody, SRY box 1 antibody, SOX18 antibody, Sox18 antibody, sox18.S antibody, sox18.L antibody, Sox1 antibody
- Background
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SOX18 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. This protein plays a role in hair, blood vessel, and lymphatic vessel development. Mutations in this gene have been associated with recessive and dominant forms of hypotrichosis-lymphedema-telangiectasia.
Alias Symbols: HLTS
Protein Interaction Partner: GKAP1, MECP2, MEF2C, HMGB1,
Protein Size: 384 - Molecular Weight
- 41 kDa
- Gene ID
- 54345
- NCBI Accession
- NM_018419, NP_060889
- UniProt
- P35713
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