DDIT4 antibody (N-Term)
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- Target See all DDIT4 Antibodies
- DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
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Binding Specificity
- AA 20-49, N-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This DDIT4 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This DDIT4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human DDIT4.
- Clone
- RB12592
- Isotype
- Ig Fraction
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anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 198-227), (C-Term) antibody
DDIT4 Reactivity: Human WB, FACS, IHC (p) Host: Rabbit Polyclonal RB11618 unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 1-232) antibodyDDIT4 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (N-Term) antibodyDDIT4 Reactivity: Human, Rat, Mouse WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (pThr23), (pThr25) antibodyDDIT4 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 1-232) antibodyDDIT4 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (AA 45-94) antibodyDDIT4 Reactivity: Human, Rat, Mouse WB Host: Rabbit Polyclonal unconjugated
anti-DNA-Damage-Inducible Transcript 4 (DDIT4) (C-Term), (N-Term) antibodyDDIT4 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB: 1:2000. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Expiry Date
- 6 months
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- Target
- DDIT4 (DNA-Damage-Inducible Transcript 4 (DDIT4))
- Alternative Name
- DDIT4 (DDIT4 Products)
- Synonyms
- redd1 antibody, Dig2 antibody, REDD-1 antibody, REDD1 antibody, 5830413E08Rik antibody, AA415483 antibody, Rtp801 antibody, dig2 antibody, rtp801 antibody, sb:cb821 antibody, zgc:64114 antibody, DNA damage inducible transcript 4 antibody, DNA-damage-inducible transcript 4 antibody, DNA damage inducible transcript 4 S homeolog antibody, ddit4 antibody, DDIT4 antibody, Ddit4 antibody, ddit4.S antibody
- Background
- REDD1 is a novel transcriptional target of p53 induced following DNA damage. During embryogenesis, REDD1 expression mirrors the tissue-specific pattern of the p53 family member p63, and TP63 null embryos show virtually no expression of REDD1, which is restored in mouse embryo fibroblasts following p63 expression. In differentiating primary keratinocytes, TP63 and REDD1 expression are coordinately downregulated, and ectopic expression of either gene inhibits in vitro differentiation. REDD1 appears to function in the regulation of reactive oxygen species (ROS), TP63 null fibroblasts have decreased ROS levels and reduced sensitivity to oxidative stress, which are both increased following ectopic expression of either TP63 or REDD1. Thus, REDD1 encodes a shared transcriptional target that implicates ROS in the p53-dependent DNA damage response and in p63-mediated regulation of epithelial differentiation.
- Molecular Weight
- 25371
- Gene ID
- 54541
- NCBI Accession
- NP_061931
- UniProt
- Q9NX09
- Pathways
- Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process
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