NDFIP2 antibody (Internal Region)
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- Target See all NDFIP2 Antibodies
- NDFIP2 (Nedd4 Family Interacting Protein 2 (NDFIP2))
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Binding Specificity
- Internal Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NDFIP2 antibody is un-conjugated
- Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificity
- NDFIP2 Antibody detects endogenous levels of total NDFIP2.
- Predicted Reactivity
- Pig,Bovine,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogen
- A synthesized peptide derived from human NDFIP2, corresponding to a region within the internal amino acids.
- Isotype
- IgG
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anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (AA 1-242) antibody
NDFIP2 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 2C7 unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (AA 152-201) antibodyNDFIP2 Reactivity: Human, Mouse, Cow, Dog, Horse, Rat, Zebrafish (Danio rerio), Guinea Pig, Pig, Bat, Chicken, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (AA 1-242) antibodyNDFIP2 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (AA 251-300) antibodyNDFIP2 Reactivity: Human, Mouse, Cow, Dog, Horse, Rat, Zebrafish (Danio rerio), Pig, Rabbit, Bat, Chicken, Monkey, Xenopus laevis WB Host: Rabbit Polyclonal unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (Middle Region) antibodyNDFIP2 Reactivity: Human, Mouse, Cow, Dog, Horse, Rat, Zebrafish (Danio rerio), Guinea Pig, Pig, Rabbit WB Host: Rabbit Polyclonal unconjugated
anti-Nedd4 Family Interacting Protein 2 (NDFIP2) (N-Term) antibodyNDFIP2 Reactivity: Human, Mouse, Cow, Dog, Horse, Rat, Zebrafish (Danio rerio), Guinea Pig WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Expiry Date
- 12 months
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- Target
- NDFIP2 (Nedd4 Family Interacting Protein 2 (NDFIP2))
- Alternative Name
- NDFIP2 (NDFIP2 Products)
- Synonyms
- MGC68708 antibody, DKFZp459H0627 antibody, N4WBP5A antibody, 0710001O20Rik antibody, 2810436B12Rik antibody, 9130207N19Rik antibody, N4wbp5a antibody, mKIAA1165 antibody, Nedd4 family interacting protein 2 S homeolog antibody, Nedd4 family interacting protein 2 antibody, ndfip2.S antibody, NDFIP2 antibody, ndfip2 antibody, Ndfip2 antibody
- Background
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Description: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity).
Gene: NDFIP2
- Molecular Weight
- 36 kDa
- Gene ID
- 54602
- UniProt
- Q9NV92
- Pathways
- Negative Regulation of Transporter Activity, SARS-CoV-2 Protein Interactome
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