TRPM4 antibody (N-Term)
(1 reference)-
- Target See all TRPM4 Antibodies
- TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
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Binding Specificity
- N-Term
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Reactivity
- Human, Rat, Mouse, Cow, Dog, Horse, Guinea Pig
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This TRPM4 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- ELLTVYSSED GSEEFETIVL KALVKACGSS EASAYLDELR LAVAWNRVDI
- Predicted Reactivity
- Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against TRPM4. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human TRPM4
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anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) antibody
TRPM4 Reactivity: Human, Dog, Monkey WB, IHC Host: Mouse Monoclonal 10H5 unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (AA 1-240) antibodyTRPM4 Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (Internal Region) antibodyTRPM4 Reactivity: Human, Rat, Mouse, Cow IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (N-Term) antibodyTRPM4 Reactivity: Human IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (AA 1-400) antibodyTRPM4 Reactivity: Rat WB, IHC, ICC, IP Host: Mouse Monoclonal C1 unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (AA 800-850) antibodyTRPM4 Reactivity: Human, Rat, Mouse WB, FACS, IF (p), IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (AA 359-408) antibodyTRPM4 Reactivity: Human, Rat, Mouse, Cow, Dog, Horse, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (AA 1-240) antibodyTRPM4 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (C-Term) antibodyTRPM4 Reactivity: Human, Gorilla IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4) (AA 1079-1214) antibodyTRPM4 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 1214 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells." in: PLoS ONE, Vol. 7, Issue 8, pp. e43859, (2012) (PubMed).
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: "KCa3.1 and TRPM7 channels at the uropod regulate migration of activated human T cells." in: PLoS ONE, Vol. 7, Issue 8, pp. e43859, (2012) (PubMed).
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- Target
- TRPM4 (Transient Receptor Potential Cation Channel, Subfamily M, Member 4 (TRPM4))
- Alternative Name
- TRPM4 (TRPM4 Products)
- Synonyms
- PFHB1B antibody, TRPM4B antibody, LTrpC-4 antibody, Mls2s antibody, 1110030C19Rik antibody, AW047689 antibody, LTRPC4 antibody, TRPM4 antibody, transient receptor potential cation channel subfamily M member 4 antibody, transient receptor potential cation channel, subfamily M, member 4 antibody, TRPM4 antibody, Trpm4 antibody
- Background
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TRPM4 is a calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca2+, it is impermeable to it. TRPM4 mediates transport of monovalent cations (Na+ > K+ > Cs+ > Li+), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca2+ oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. TRPM4 is involved in myogenic constriction of cerebral arteries. It controls insulin secretion in pancreatic beta-cells. TRPM4 may also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca2+ overload.
Alias Symbols: FLJ20041, TRPM4B, PFHB1B
Protein Interaction Partner: FUS, UBC, TRPM4,
Protein Size: 1214 - Molecular Weight
- 134 kDa
- Gene ID
- 54795
- NCBI Accession
- NM_017636, NP_060106
- UniProt
- Q8TD43
- Pathways
- Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response
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