FBXW7 antibody (C-Term)
(1 reference)-
- Target See all FBXW7 Antibodies
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Binding Specificity
- C-Term
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Reactivity
- Human, Mouse, Rat, Dog, Cow, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FBXW7 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- LKTGEFIRNL VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Characteristics
- This is a rabbit polyclonal antibody against FBXW7. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human FBXW7
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anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 501-600) antibody
FBXW7 Reactivity: Human, Mouse, Rat WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibodyFBXW7 Reactivity: Human WB, ELISA, IHC (p) Host: Mouse Monoclonal 3D1 unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 408-707) antibodyFBXW7 Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-627) antibodyFBXW7 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 1-707) antibodyFBXW7 Reactivity: Human IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) antibodyFBXW7 Reactivity: Human, Mouse IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-707) antibodyFBXW7 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 599-708) antibodyFBXW7 Reactivity: Human WB, IHC, ELISA, IHC (p) Host: Mouse Monoclonal 3D1 unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (C-Term) antibodyFBXW7 Reactivity: Human, Mouse, Rat, Dog, Cow, Pig, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Horse, Drosophila melanogaster, Monkey, Xenopus laevis, Hamster, Chicken, Bat WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-F-Box and WD Repeat Domain Containing 7 (FBXW7) (AA 251-300) antibodyFBXW7 Reactivity: Mouse, Rat, Hamster WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 589 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins." in: Nature genetics, Vol. 46, Issue 6, pp. 588-94, (2014) (PubMed).
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: "Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins." in: Nature genetics, Vol. 46, Issue 6, pp. 588-94, (2014) (PubMed).
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- Target
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Alternative Name
- FBXW7 (FBXW7 Products)
- Background
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FBXW7 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in FBXW7 gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers.
Alias Symbols: AGO, CDC4, FBW6, FBW7, FBX30, FBXO30, FBXW6, SEL-10, SEL10, hAgo, hCdc4
Protein Interaction Partner: MCL1, CDC34, CCNE1, FBXW7, CUL1, UBE2D1, PIN1, DAB2IP, YAP1, SKP1, MAP4K1, EYA1, KLF5, SREBF1, NOTCH1, UBE2QL1, Creb3l2, Creb3l1, SIC1, CSF3R, KLF2, NCOA3, PTEN, NFE2L1, HSP90AA1, MED11, MED19, MED8, MED30, MED10, MED28, MED29, MED9, MED15, MED31, MED4, M
Protein Size: 707 - Molecular Weight
- 80 kDa
- Gene ID
- 55294
- NCBI Accession
- NM_001013415, NP_001013433
- Pathways
- Notch Signaling, EGFR Signaling Pathway
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