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PARL antibody (N-Term)

Name: PARL antibody (N-Term)
SKU: ABIN2782038
Price: 472.77 USD
Availability: InStock

PARL Reactivity: Human, Mouse, Rat, Dog, Pig, Rabbit, Horse, Cow, Guinea Pig WB, IHC Host: Rabbit Polyclonal unconjugated

WB Suggested Anti-PARL Antibody Titration: 0.

Immunohistochemistry (IHC) image for anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibody (ABIN2782038)

IHC

IHC

Host: Rabbit Target Name: PARL Sample Tissue: Human Jurkat Antibody Dilution: 1.

Rabbit Anti-PARL Antibody Formalin Fixed Paraffin Embedded Tissue: Human Lung Tissue Observed Staining: Cytoplasmic in alveolar type I cells Primary Antibody Concentration: 1:100 Other Working Concentrations: 1/600 Secondary Antibody: Donkey anti-Rabbit-Cy3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.

IHC

5 images

(1 reference)

Catalog No. ABIN2782038

Datasheet as PDF

Target See all PARL Antibodies

PARL (Presenilin Associated, Rhomboid-Like (PARL))
Binding Specificity
3

2

2

2

1

1

1

1

1
N-Term
Reactivity
20

8

7

2

2

1

1

1

1

1

1

1
Human, Mouse, Rat, Dog, Pig, Rabbit, Horse, Cow, Guinea Pig
Host
16

3

2
Rabbit
Compatible Secondaries
Clonality
18

3
Polyclonal
Conjugate
14

1

1

1

1

1

1

1
This PARL antibody is un-conjugated
Application
11

9

6

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

Sequence

SLIKPLFFTV GFTGCAFGSA AIWQYESLKS RVQSYFDGIK ADWLDSIRPQ

Predicted Reactivity

Cow: 93%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%,

Characteristics

This is a rabbit polyclonal antibody against PARL. It was validated on Western Blot and immunohistochemistry.

Purification

Affinity Purified

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human PARL
anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 1-170) antibody
PARL Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated

anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 112-167) antibody
PARL Reactivity: Human WB, ELISA Host: Mouse Monoclonal 8C4B2 unconjugated

anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 97-146) antibody
PARL Reactivity: Human, Mouse, Rat, Dog, Pig, Rabbit, Horse, Bat, Monkey WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated

anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 1-170) antibody
PARL Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated

anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 2-100) antibody
PARL Reactivity: Human ELISA Host: Mouse Monoclonal 4F4 unconjugated

anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibody
PARL Reactivity: Human, Mouse, Rat WB, IF, EIA Host: Rabbit Polyclonal unconjugated

anti-Presenilin Associated, Rhomboid-Like (PARL) (AA 40-90), (N-Term) antibody
PARL Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated

anti-Presenilin Associated, Rhomboid-Like (PARL) (C-Term) antibody
PARL Reactivity: Human, Mouse, Rat, Chicken, Primate WB, ELISA, IHC, FM Host: Rabbit Polyclonal unconjugated

anti-Presenilin Associated, Rhomboid-Like (PARL) antibody
PARL Reactivity: Human, Mouse, Rat, Dog WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated

anti-Presenilin Associated, Rhomboid-Like (PARL) (N-Term) antibody
PARL Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated

Application Notes

Optimal working dilutions should be determined experimentally by the investigator.

Comment

Antigen size: 329 AA

Restrictions

For Research Use only
Format

Liquid

Concentration

Lot specific

Buffer

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice

Avoid repeated freeze-thaw cycles.

Storage

-20 °C

Storage Comment

For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Yoshioka, Katsu, Sakata, Okami, Wakai, Kinouchi, Chan: "The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia." in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, Vol. 33, Issue 11, pp. 1658-65, (2013) (PubMed).
Target

PARL (Presenilin Associated, Rhomboid-Like (PARL))

Alternative Name

PARL (PARL Products)

Synonyms

PSARL antibody, PSARL1 antibody, PSENIP2 antibody, RHBDS1 antibody, D16Ertd607e antibody, PRO2207 antibody, Psarl antibody, parl antibody, zgc:112986 antibody, presenilin associated rhomboid like antibody, presenilin associated, rhomboid-like antibody, presenilin associated, rhomboid-like a antibody, PARL antibody, Parl antibody, parla antibody

Background

PARL is a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. PARL may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in its gene has been associated with increased risk for type 2 diabetes.This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: PRO2207, PSARL, PSARL1, PSENIP2, RHBDS1
Protein Interaction Partner: UBC, PINK1,
Protein Size: 329

Molecular Weight

36 kDa

Gene ID

55486

NCBI Accession

NM_001037639, NP_001032728

Pathways

Autophagy