MAML3 antibody
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- Target See all MAML3 Antibodies
- MAML3 (Mastermind-Like 3 (MAML3))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This MAML3 antibody is un-conjugated
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Application
- Immunostaining (ISt), Immunohistochemistry (IHC), Staining Methods (StM)
- Purification
- Purified by Protein A/G
- Immunogen
- Recombinant human MAML3 protein fragment
- Clone
- MAML3-1303
- Isotype
- IgG1 kappa
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anti-Mastermind-Like 3 (MAML3) (AA 640-665), (C-Term) antibody
MAML3 Reactivity: Human FACS, WB, IHC (p) Host: Rabbit Polyclonal RB18761 unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 Reactivity: Human FACS, IF, IHC (p) Host: Mouse Monoclonal MAML3-1303 unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 1024-1131) antibodyMAML3 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 Reactivity: Human FACS, WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 791-840) antibodyMAML3 Reactivity: Human, Mouse, Horse, Rabbit, Dog, Guinea Pig, Chicken, Monkey WB Host: Rabbit Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 Reactivity: Human FACS, IF, IHC (p) Host: Mouse Monoclonal MAML3-1303 unconjugated
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- Application Notes
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Positive Control: MCF-7 cells. Pancreas or Placenta. Cervix or Colon Carcinoma.
Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Expiry Date
- 24 months
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- Target
- MAML3 (Mastermind-Like 3 (MAML3))
- Alternative Name
- MAML3 (MAML3 Products)
- Synonyms
- AV234550 antibody, BC049812 antibody, Mam-2 antibody, mKIAA1816 antibody, Glrp1 antibody, CAGH3 antibody, ERDA3 antibody, GDN antibody, MAM-2 antibody, MAM2 antibody, TNRC3 antibody, mastermind like 3 (Drosophila) antibody, mastermind-like transcriptional coactivator 3 antibody, mastermind like transcriptional coactivator 3 antibody, Maml3 antibody, MAML3 antibody
- Background
- MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
- Molecular Weight
- 150-170kDa
- Gene ID
- 55534
- UniProt
- Q96JK9
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