PRKG2 antibody (C-Term)
(4 references)-
- Target See all PRKG2 Antibodies
- PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))
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Binding Specificity
- AA 714-744, C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PRKG2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This cGKII antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 714-744 amino acids from the C-terminal region of human cGKII.
- Clone
- RB01036
- Isotype
- Ig Fraction
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anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (Internal Region) antibody
PRKG2 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (Ser363), (Thr359) antibodyPRKG2 Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) antibodyPRKG2 Reactivity: Human WB, IP, IF Host: Rabbit Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (AA 453-728) antibodyPRKG2 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (Ser126) antibodyPRKG2 Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (N-Term) antibodyPRKG2 Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (AA 1-100) antibodyPRKG2 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (N-Term) antibodyPRKG2 Reactivity: Human, Mouse WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Protein Kinase, CGMP-Dependent, Type II (PRKG2) (C-Term) antibodyPRKG2 Reactivity: Human WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Expiry Date
- 6 months
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: "Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells." in: Molecular medicine reports, Vol. 13, Issue 2, pp. 1909-13, (2016) (PubMed).
: "Nitric oxide/cyclic guanosine monophosphate inducers sodium nitroprusside and L-arginine inhibit the proliferation of gastric cancer cells via the activation of type II cyclic guanosine ..." in: Oncology letters, Vol. 10, Issue 1, pp. 479-484, (2015) (PubMed).
: "Type II cyclic guanosine monophosphate-dependent protein kinase inhibits epidermal growth factor receptor activation in different cancer cell lines." in: Oncology letters, Vol. 9, Issue 6, pp. 2781-2786, (2015) (PubMed).
: "Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14796-808, (2009) (PubMed).
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: "Type II cGMP-dependent protein kinase directly inhibits HER2 activation of gastric cancer cells." in: Molecular medicine reports, Vol. 13, Issue 2, pp. 1909-13, (2016) (PubMed).
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- Target
- PRKG2 (Protein Kinase, CGMP-Dependent, Type II (PRKG2))
- Alternative Name
- cGKII (PRKG2 Products)
- Synonyms
- MGC82580 antibody, PRKG2 antibody, si:dkey-18e17.2 antibody, PRKGR2 antibody, cGKII antibody, GDPKII antibody, AW212535 antibody, CGKII antibody, Prkgr2 antibody, cGK-II antibody, protein kinase, cGMP-dependent, type II antibody, protein kinase, cGMP-dependent, type II L homeolog antibody, cGMP-dependent protein kinase 2 antibody, PRKG2 antibody, prkg2.L antibody, prkg2 antibody, LOC100541294 antibody, Prkg2 antibody
- Background
- CGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Edentification of the pathway that mediates intestinal fluid secretion by E. coli STa has potential medical implications because STa causes traveler's diarrhea and about 50 % of infant mortality in developing countries. Transfection experiments in human cells disclose that cGKII phosphorylates SOX9 and attenuates SOX9 function by inhibiting its nuclear entry. Impaired differentiation of cultured KMI chondrocytes can be restored by silencing Sox9 by RNA interference. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.
- Molecular Weight
- 87432
- Gene ID
- 5593
- NCBI Accession
- NP_006250
- UniProt
- Q13237
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