ZFYVE28 antibody
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- Target See all ZFYVE28 Antibodies
- ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This ZFYVE28 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Staining Methods (StM)
- Purification
- Purified by Protein A/G
- Immunogen
- Recombinant full-length human ZFYVE28 protein
- Clone
- LST2-2426
- Isotype
- IgG2a kappa
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anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (AA 604-633), (C-Term) antibody
ZFYVE28 Reactivity: Human IHC (p) Host: Rabbit Polyclonal RB27835 unconjugated
anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (AA 1-887) antibodyZFYVE28 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (AA 131-180) antibodyZFYVE28 Reactivity: Human, Mouse, Rat, Cow, Dog, Pig WB Host: Rabbit Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (AA 604-633), (C-Term) antibodyZFYVE28 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Zinc Finger, FYVE Domain Containing 28 (ZFYVE28) (AA 611-642), (C-Term) antibodyZFYVE28 Reactivity: Human, Mouse WB, IHC (p), EIA Host: Rabbit Polyclonal unconjugated
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- Application Notes
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Positive Control: PC3 cells. Testis, Brain, Colon, Kidney or Stomach.
Known Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Expiry Date
- 24 months
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- Target
- ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))
- Alternative Name
- ZFYVE28 (ZFYVE28 Products)
- Synonyms
- LST2 antibody, LYST2 antibody, 9630058O20Rik antibody, Gm146 antibody, mKIAA1643 antibody, id:ibd1374 antibody, zgc:152894 antibody, zinc finger FYVE-type containing 28 antibody, zinc finger, FYVE domain containing 28 antibody, ZFYVE28 antibody, Zfyve28 antibody, zfyve28 antibody
- Background
- ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs.
- Molecular Weight
- 96kDa
- Gene ID
- 57732
- Pathways
- EGFR Signaling Pathway
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