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TXNRD1 antibody (AA 451-550)

TXNRD1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386102
  • Target See all TXNRD1 Antibodies
    TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))
    Binding Specificity
    • 14
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 451-550
    Reactivity
    Human, Mouse, Rat
    Host
    • 40
    • 5
    • 1
    Rabbit
    Clonality
    • 35
    • 11
    Polyclonal
    Conjugate
    • 20
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This TXNRD1 antibody is un-conjugated
    Application
    • 32
    • 13
    • 13
    • 11
    • 9
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Human, Mouse, Rat
    Predicted Reactivity
    Dog,Cow,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TXNRD1
    Isotype
    IgG
    Top Product
    Discover our top product TXNRD1 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Kaya, Çiçek, Erdi, Findik, Karatas, Esen, Keskin, Kalkan: "Intratumoral hemorrhage-related differences in the expression of vascular endothelial growth factor, basic fibroblast growth factor and thioredoxin reductase 1 in human glioblastoma." in: Molecular and clinical oncology, Vol. 5, Issue 4, pp. 343-346, (2016) (PubMed).

  • Target
    TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))
    Alternative Name
    Txnrd1 (TXNRD1 Products)
    Background

    Synonyms: TR, TR1, TXNR, TRXR1, GRIM-12, Thioredoxin reductase 1, cytoplasmic, Gene associated with retinoic and interferon-induced mortality 12 protein, Gene associated with retinoic and IFN-induced mortality 12 protein, KM-12-derived reductase-like factor, Thioredoxin reductase TR1, TXNRD1, GRIM12, KDRF

    Background: Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.

    Gene ID
    7296
    UniProt
    Q16881
    Pathways
    Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis
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