Chp2 antibody
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- Target See all Chp2 products
- Chp2
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Chp2 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Purification
- Purified by Protein A/G
- Immunogen
- Recombinant human full-length CHP2 protein
- Clone
- CPTC-CHP2-1
- Isotype
- IgG2c kappa
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anti-Chp2 (Internal Region) antibody
Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Chp2 (Internal Region) antibodyReactivity: Human, Mouse, Rat WB, ELISA, IF, ICC, IHC Host: Rabbit Polyclonal unconjugated
anti-Chp2 (Internal Region) antibodyReactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-Chp2 (Center) antibodyReactivity: Human, Mouse, Rat, Monkey WB, IP Host: Rabbit Polyclonal unconjugated
anti-Chp2 (AA 101-150) antibodyReactivity: Human, Mouse, Rat WB, ELISA Host: Rabbit Polyclonal unconjugated
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- Application Notes
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Positive Control: MCF-7, PC-3, HT29, K562 or Jurkat cell lysates. Human appendix or testis.
Known Application: Western Blot (1-2 μg/mL), Immunofluorescence (1-2 μg/mL),Optimal dilution for a specific application should be determined.
- Restrictions
- For Research Use only
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- Concentration
- 200 μg/mL
- Buffer
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-80 °C
- Storage Comment
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- Expiry Date
- 24 months
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- Target
- Chp2
- Abstract
- Chp2 Products
- Synonyms
- 2010110P09Rik antibody, Cbhp2 antibody, chp-2 antibody, calcineurin-like EF hand protein 2 antibody, calcineurin like EF-hand protein 2 antibody, Chp2 antibody, CHP2 antibody
- Background
- CHP2 (calcineurin B homologous protein 2), also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
- Molecular Weight
- 22kDa
- Gene ID
- 63928
- UniProt
- O43745
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