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NOD2 antibody (AA 611-910)

NOD2 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7269065
  • Target See all NOD2 Antibodies
    NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))
    Binding Specificity
    • 16
    • 5
    • 5
    • 4
    • 3
    • 2
    • 1
    AA 611-910
    Reactivity
    • 38
    • 5
    • 4
    Human
    Host
    • 37
    • 3
    • 1
    Rabbit
    Clonality
    • 39
    • 2
    Polyclonal
    Conjugate
    • 20
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOD2 antibody is un-conjugated
    Application
    • 35
    • 17
    • 14
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Purpose
    NOD2 Rabbit pAb
    Sequence
    AAFYLALSAD VPPALLRHLF NCGRPGNSPM ARLLPTMCIQ ASEGKDSSVA ALLQKAEPHN LQITAAFLAG LLSREHWGLL AECQTSEKAL LRRQACARWC LARSLRKHFH SIPPAAPGEA KSVHAMPGFI WLIRSLYEMQ EERLARKAAR GLNVGHLKLT FCSVGPTECA ALAFVLQHLR RPVALQLDYN SVGDIGVEQL LPCLGVCKAL YLRDNNISDR GICKLIECAL HCEQLQKLAL FNNKLTDGCA HSMAKLLACR QNFLALRLGN NYITAAGAQV LAEGLRGNTS LQFLGFWGNR
    Cross-Reactivity
    Human, Mouse, Rat
    Characteristics
    Polyclonal Antibodies
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 611-910 of human NOD2 (NP_071445.1).
    Isotype
    IgG
  • Application Notes
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))
    Alternative Name
    NOD2 (NOD2 Products)
    Synonyms
    ACUG antibody, BLAU antibody, CARD15 antibody, CD antibody, CLR16.3 antibody, IBD1 antibody, NLRC2 antibody, NOD2B antibody, PSORAS1 antibody, Card15 antibody, F830032C23Rik antibody, Nlrc2 antibody, caspase recruitment domain 15 protein antibody, nucleotide binding oligomerization domain containing 2 antibody, nucleotide-binding oligomerization domain containing 2 antibody, TTHERM_01951320 antibody, NOD2 antibody, Nod2 antibody
    Background
    This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.,NOD2,ACUG,BLAU,BLAUS,CARD15,CD,CLR16.3,IBD1,NLRC2,NOD2B,PSORAS1,YAOS,Cell Biology & Developmental Biology,Apoptosis,Caspases,NOD2
    Molecular Weight
    22kDa/112kDa/115kDa
    Gene ID
    64127
    UniProt
    Q9HC29
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome
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