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DCLRE1C antibody (C-Term)

Name: DCLRE1C antibody (C-Term)
SKU: ABIN6261238
Price: 390.77 USD
Availability: InStock

DCLRE1C Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated

Western blot analysis of Hela whole cell lysates, using DCLRE1C Antibody.

IF/ICC

ABIN6277660 at 1/100 staining Mouse kidney tissue by IHC-P.

IHC

3 images

Catalog No. ABIN6261238

Datasheet as PDF

Target See all DCLRE1C Antibodies

DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))
Binding Specificity
15

10

8

7

4

3

2

2

2

1

1

1

1

1

1

1

1
C-Term
Reactivity
43

27

23

4

4

3

3

3

2

2

1

1
Human, Mouse, Rat
Host
58

1
Rabbit
Compatible Secondaries
Clonality
59
Polyclonal
Conjugate
28

4

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1
This DCLRE1C antibody is un-conjugated
Application
45

27

22

13

13

8

4

3

1

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificity

DCLRE1C Antibody detects endogenous levels of total DCLRE1C.

Predicted Reactivity

Pig,Bovine,Horse,Sheep,Rabbit

Purification

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen

A synthesized peptide derived from human DCLRE1C, corresponding to a region within C-terminal amino acids.

Isotype

IgG
anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 21-50), (N-Term) antibody
DCLRE1C Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB24410 unconjugated

anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 482-495) antibody
DCLRE1C Reactivity: Human WB, ELISA, IHC Host: Goat Polyclonal unconjugated

anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 21-50) antibody
DCLRE1C Reactivity: Human, Mouse WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated

anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 301-400) antibody
DCLRE1C Reactivity: Rat WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated

anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 1-434) antibody
DCLRE1C Reactivity: Human WB Host: Rabbit Polyclonal unconjugated

anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 396-445) antibody
DCLRE1C Reactivity: Human, Rat, Guinea Pig, Horse, Dog, Monkey, Bat WB Host: Rabbit Polyclonal unconjugated

anti-DNA Cross-Link Repair 1C (DCLRE1C) (N-Term) antibody
DCLRE1C Reactivity: Human, Mouse, Rat, Guinea Pig, Horse, Cow, Rabbit, Zebrafish (Danio rerio), Monkey, Pig WB Host: Rabbit Polyclonal unconjugated

anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 482-531), (pSer516) antibody
DCLRE1C Reactivity: Human, Mouse WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated

anti-DNA Cross-Link Repair 1C (DCLRE1C) (AA 482-531) antibody
DCLRE1C Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-DNA Cross-Link Repair 1C (DCLRE1C) (pSer516) antibody
DCLRE1C Reactivity: Human, Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated

Application Notes

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date

12 months
Target

DCLRE1C (DNA Cross-Link Repair 1C (DCLRE1C))

Alternative Name

DCLRE1C (DCLRE1C Products)

Synonyms

artemis antibody, A-SCID antibody, DCLREC1C antibody, RS-SCID antibody, SCIDA antibody, SNM1C antibody, hSNM1C antibody, Snm1l antibody, nuclease antibody, 9930121L06Rik antibody, AI661365 antibody, Art antibody, DNA cross-link repair 1C antibody, DCLRE1C antibody, Dclre1c antibody

Background

Description: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ.
Gene: DCLRE1C

Molecular Weight

78kDa

Gene ID

64421

UniProt

Q96SD1

Pathways

DNA Damage Repair