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BIM antibody (pSer87)

Name: BIM antibody (pSer87)
SKU: ABIN682873
Price: 384.62 USD
Availability: InStock

BCL2L11 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti phospho-Bim(Ser87) Polyclonal Antibody, Unconjugated (ABIN682873) at 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC

Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti-Bim(Ser87) Polyclonal Antibody, Unconjugated at 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC (p)

2 images

(2 references)

Catalog No. ABIN682873

Datasheet as PDF

Target See all BIM (BCL2L11) Antibodies

BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
Binding Specificity
16

15

14

8

7

7

7

7

7

7

7

7

6

6

5

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer87
Reactivity
177

100

90

5

3

3

2

1

1

1
Human, Mouse, Rat
Host
165

9

5

1
Rabbit
Compatible Secondaries
Clonality
151

29
Polyclonal
Conjugate
67

16

9

8

8

7

7

7

7

7

7

7

4

4

4

4

2

1

1

1

1

1
This BIM antibody is un-conjugated
Application
122

65

50

28

25

21

15

14

13

12

10

5

4

4

1

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity

Human, Mouse, Rat

Predicted Reactivity

Dog,Cow,Sheep,Pig,Horse

Purification

Purified by Protein A.

Immunogen

KLH conjugated synthetic phosphopeptide derived from human Bim around the phosphorylation site of Ser87

Isotype

IgG

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anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) antibody (HRP)
BCL2L11 Reactivity: Human WB, IHC Host: Rabbit Polyclonal HRP

anti-BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11) antibody
BCL2L11 Reactivity: Human WB, IF, ICC Host: Rabbit Polyclonal unconjugated

Application Notes

WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage

4 °C,-20 °C

Storage Comment

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date

12 months
Lee, Maeng, Kang, Choi, Oh, Ju, Yune: "Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury." in: Journal of neurotrauma, Vol. 31, Issue 6, pp. 582-94, (2014) (PubMed).

Gogada, Yadav, Liu, Tang, Zhang, Schneider, Seshadri, Sun, Aldaz, Tang, Chandra: "Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer." in: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 368-81, (2013) (PubMed).
Target

BIM (BCL2L11) (BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))

Alternative Name

Bim (BCL2L11 Products)

Synonyms

bim antibody, BAM antibody, BIM antibody, BOD antibody, 1500006F24Rik antibody, Bim antibody, Bod antibody, BimL antibody, BIMEL antibody, BCL2-like 11 antibody, BCL2 like 11 antibody, BCL2-like 11 (apoptosis facilitator) antibody, bcl2l11 antibody, BCL2L11 antibody, Bcl2l11 antibody

Background

Synonyms: BAM, BIM, BOD, Bcl-2-like protein 11, Bcl2-L-11, Bcl2-interacting mediator of cell death, BCL2L11, pBIM
Background: Induces apoptosis and anoikis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than isoform BimEL, isoform BimL and isoform BimS. Isoform Bim-gamma induces apoptosis. Isoform Bim-alpha3 induces apoptosis possibly through a caspase-mediated pathway. Isoform BimAC and isoform BimABC lack the ability to induce apoptosis.

Gene ID

10018

UniProt

O43521

Pathways

PI3K-Akt Signaling, Neurotrophin Signaling Pathway, Tube Formation, Positive Regulation of Endopeptidase Activity