WNK3 antibody (AA 451-550)
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- Target See all WNK3 Antibodies
- WNK3 (WNK Lysine Deficient Protein Kinase 3 (WNK3))
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Binding Specificity
- AA 451-550
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This WNK3 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Cross-Reactivity
- Human, Rat
- Predicted Reactivity
- Mouse,Cow,Rabbit
- Purification
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human WNK3 protein
- Isotype
- IgG
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anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 500-600) antibody
WNK3 Reactivity: Human WB, IF Host: Rabbit Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) antibodyWNK3 Reactivity: Human, Mouse, Rat IHC Host: Rabbit Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) antibodyWNK3 Reactivity: Human WB, IHC, ELISA Host: Rabbit Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (C-Term) antibodyWNK3 Reactivity: Human, Mouse, Rat WB, IHC, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 1586-1616), (C-Term) antibodyWNK3 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal RB3339 unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 1-100) antibodyWNK3 Reactivity: Human WB, ELISA Host: Mouse Monoclonal 4H5 unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 1018-1181) antibodyWNK3 Reactivity: Human ELISA, IF Host: Rabbit Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 1-100) antibodyWNK3 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) antibodyWNK3 Reactivity: Mouse WB Host: Rabbit Polyclonal unconjugated
anti-WNK Lysine Deficient Protein Kinase 3 (WNK3) (AA 431-480) antibodyWNK3 Reactivity: Human, Mouse, Rabbit, Cow, Dog, Guinea Pig, Horse, Bat, Monkey, Pig WB, IHC, IHC (p) Host: Rabbit Polyclonal unconjugated
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- Application Notes
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- Expiry Date
- 12 months
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- Target
- WNK3 (WNK Lysine Deficient Protein Kinase 3 (WNK3))
- Alternative Name
- WNK3 protein (WNK3 Products)
- Synonyms
- fc63h12 antibody, PRKWNK3 antibody, Prkwnk3 antibody, Wnk3-ps antibody, RGD1563131 antibody, wu:fc63h12 antibody, WNK lysine deficient protein kinase 3 antibody, wu:fc63h12 antibody, LOC100363278 antibody, WNK3 antibody, Wnk3 antibody
- Background
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Synonyms: PRKWNK3, Serine/threonine-protein kinase WNK3, Protein kinase lysine-deficient 3, Protein kinase with no lysine 3, WNK3, KIAA1566
Background: Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway. Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. Isoform 1, isoform 2, isoform 3 and isoform 4 stimulate the activity of SLC12A1, SLC12A2 and SLC12A3 and inhibit the activity of SLC12A4, SLC12A5, SLC12A6 and SLC12A7. According to PubMed:19470686, isoform 1 inhibits the activity of SLC12A3.
- Gene ID
- 65267
- UniProt
- Q9BYP7
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