RNF146 antibody
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- Target See all RNF146 Antibodies
- RNF146 (Ring Finger Protein 146 (RNF146))
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RNF146 antibody is un-conjugated
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Application
- ELISA, Immunohistochemistry (IHC)
- Characteristics
- Polyclonal Antibody
- Purification
- Antigen affinity purification
- Immunogen
- Fusion protein of human RNF146
- Isotype
- IgG
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anti-Ring Finger Protein 146 (RNF146) (AA 1-110) antibody
RNF146 Reactivity: Human WB, ELISA Host: Mouse Polyclonal unconjugated
anti-Ring Finger Protein 146 (RNF146) (C-Term) antibodyRNF146 Reactivity: Human, Mouse, Dog, Horse WB Host: Rabbit Polyclonal unconjugated
anti-Ring Finger Protein 146 (RNF146) (AA 1-358) antibodyRNF146 Reactivity: Human WB Host: Mouse Polyclonal unconjugated
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- Application Notes
- IHC 1:30-1:150, ELISA 1:5000-1:10000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.02 mg/mL
- Buffer
- PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- RNF146 (Ring Finger Protein 146 (RNF146))
- Alternative Name
- RNF146 (RNF146 Products)
- Synonyms
- RP3-351K20.1 antibody, dJ351K20.1 antibody, 2610509H23Rik antibody, Iduna antibody, RNF146 antibody, rnf146 antibody, dactylidin antibody, wu:fi29e08 antibody, zgc:55909 antibody, ring finger protein 146 antibody, RING finger protein 146 antibody, ring finger protein 146 S homeolog antibody, RNF146 antibody, Rnf146 antibody, rn146 antibody, rnf146.S antibody, rnf146 antibody
- Background
- E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein. Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos. Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner. Does not affect PARP1 activation (By similarity). Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest. Promotes cell survival after gamma-irradiation. Facilitates DNA repair.
- UniProt
- Q9NTX7
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