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GBA antibody

GBA Reactivity: Mouse, Rat IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7074062
  • Target See all GBA Antibodies
    GBA (Glucosidase, Beta, Acid (GBA))
    Reactivity
    • 53
    • 28
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse, Rat
    Host
    • 63
    • 10
    Rabbit
    Clonality
    • 56
    • 17
    Polyclonal
    Conjugate
    • 32
    • 15
    • 9
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This GBA antibody is un-conjugated
    Application
    • 53
    • 25
    • 25
    • 8
    • 8
    • 6
    • 5
    • 5
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Rat
    Purification
    Affinity purification
    Immunogen
    KLH conjugated Synthetic peptide corresponding to Mouse GBA
    Top Product
    Discover our top product GBA Primary Antibody
  • Application Notes
    IHC/IF (M,R) 1:1000-1:2000/1:500-1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS, pH 7.4, 0.02 % sodium azide
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    GBA (Glucosidase, Beta, Acid (GBA))
    Alternative Name
    GBA (GBA Products)
    Synonyms
    GBA1 antibody, GCB antibody, GLUC antibody, BETA-GLUCOSIDASE antibody, T12J13.8 antibody, T12J13_8 antibody, beta glucosidase 25 antibody, PSPTO3318 antibody, PSPTO4290 antibody, GC antibody, GCase antibody, betaGC antibody, glucosylceramidase beta antibody, beta glucosidase 25 antibody, beta-glucosidase antibody, Beta-glucosidase antibody, glucosidase, beta, acid antibody, glucosylceramidase antibody, bglX-2 antibody, GBA antibody, BGLU25 antibody, PSPTO_3318 antibody, bglX antibody, bglA4 antibody, Gba antibody, LOC100399524 antibody, bglA.2 antibody, bglX-2 antibody
    Background
    The GBA is a glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramide/GlcCer into free ceramide and glucose. Thereby, plays a central role in the degradation of complex lipids and the turnover of cellular membranes . Through the production of ceramides, participates to the PKC-activated salvage pathway of ceramide formation. Also plays a role in cholesterol metabolism . May either catalyze the glucosylation of cholesterol, through a transglucosylation reaction that transfers glucose from glucosylceramide to cholesterol . The short chain saturated C8:0-GlcCer and the mono-unsaturated C18:0-GlcCer being the most effective glucose donors for that transglucosylation reaction. Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl-beta-D-glucoside to ceramide. Finally, may also hydrolyze cholesteryl-beta-D-glucoside to produce D-glucose and cholesterol .
    Gene ID
    14466
    NCBI Accession
    NP_001070879
    UniProt
    P17439
    Pathways
    Cellular Glucan Metabolic Process
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