MAP3K7 antibody (pThr187)
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- Target See all MAP3K7 Antibodies
- MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))
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Binding Specificity
- pThr187
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This MAP3K7 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificity
- Phospho-TAK1 (Thr187) Antibody detects endogenous levels of TAK1 only when phosphorylated at Threonine 187.
- Predicted Reactivity
- Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- Immunogen
- A synthesized peptide derived from human TAK1 around the phosphorylation site of Thr187.
- Isotype
- IgG
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anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (AA 300-470) antibody
MAP3K7 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (AA 1-579) antibodyMAP3K7 Reactivity: Human WB, IF, IP Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (AA 131-160), (N-Term) antibodyMAP3K7 Reactivity: Human, Mouse WB, IHC (p) Host: Rabbit Polyclonal RB34632 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (Internal Region) antibodyVerified MAP3K7 Reactivity: Human, Mouse WB, ELISA, FACS Host: Goat Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (AA 1-579) antibodyMAP3K7 Reactivity: Human WB, IF, PLA Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (Thr187) antibodyMAP3K7 Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (AA 471-579) antibodyMAP3K7 Reactivity: Human WB, ELISA, IHC, ICC, FACS Host: Mouse Monoclonal 3E8H4 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (AA 1-579) antibodyMAP3K7 Reactivity: Human WB, ELISA, RNAi Host: Mouse Monoclonal 2E10 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (C-Term) antibodyMAP3K7 Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7) (pSer412) antibodyMAP3K7 Reactivity: Human WB Host: Rabbit Polyclonal unconjugated
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- Application Notes
- WB 1:500-1:2000, IHC 1:50-1:500, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20 °C. Stable for 12 months from date of receipt.
- Expiry Date
- 12 months
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- Target
- MAP3K7 (Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))
- Alternative Name
- MAP3K7 (MAP3K7 Products)
- Synonyms
- si:ch211-225h9.1 antibody, zgc:110612 antibody, Tak1 antibody, MEKK7 antibody, TAK1 antibody, TGF1a antibody, B430101B05 antibody, C87327 antibody, mitogen-activated protein kinase kinase kinase 7 antibody, mitogen activated protein kinase kinase kinase 7 antibody, map3k7 antibody, Map3k7 antibody, MAP3K7 antibody
- Background
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Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.
Gene: MAP3K7
- Molecular Weight
- 70kDa
- Gene ID
- 6885
- UniProt
- O43318
- Pathways
- NF-kappaB Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway
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